Discussion on the Correlation Between the Structure-Activity Imbalance of Lung Collaterals and the Biomechanical Properties of Idiopathic Pulmonary Fibrosis
- VernacularTitle:肺络构效失衡与特发性肺纤维化生物力学特性机制相关性探微
- Author:
Yongming LIU
1
;
Yuanyu LIANG
;
Lijian PANG
;
Ningzi ZANG
;
Jingyu WANG
;
Jiyu ZOU
;
Jiaran WANG
;
Zhongxue ZHAO
;
Yu ZHENG
;
Xiaodong LYU
Author Information
- Publication Type:Journal Article
- Keywords: Idiopathic pulmonary fibrosis; Structure-activity of lung collaterals; Biomechanics; Extracellular matrix; Pathogenesis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(4):931-938
- CountryChina
- Language:Chinese
- Abstract: Guided by the pathogenesis of"structure-activity imbalance of lung collaterals",this paper proposes that structure-activity imbalance of lung collaterals is the initial factor of idiopathic pulmonary fibrosis(IPF)and elucidates the pathogenesis of abnormal changes in biomechanical properties of IPF.It is postulated that the changes of biomechanical properties of lung tissue are closely related to the injury of lung qi collaterals,the abnormal mechanical stress are closely related to the injury of lung blood collaterals,and the biomechanical response of intrapulmonary resident cells is closely related to the structure-activity imbalance of lung collaterals,which ultimately leading to abnormal increase in lung tissue stiffness and progressive scarring formation in lung tissue.Integrating traditional pathogenesis concepts with microscopic pathological changes,and the in-depth exploration of the correlation between the structure-activity imbalance of lung collaterals and the biomechanical properties of IPF can provide direction for exploring IPF medical-engineering cross research,which are of great significance for enriching the syndrome and treatment system of lung collateral diseases.
