Treatment and repair of musculoskeletal degenerative diseases and injuries from the perspective of muscle-bone crosstalk mechanism
- VernacularTitle:肌骨交互机制视域下肌骨退行性疾病及损伤的治疗与修复
- Author:
Xingyu ZHANG
1
;
Dou WU
1
;
Enzhe ZHAO
1
;
Xubin SONG
1
;
Xiaolun ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: muscle-bone interaction; musculoskeletal system; inter-tissue communication; myokines; osteokines; osteosarcopenia; sarcopenia; osteoporosis; bone regeneration; fibro-adipogenic progenitors; engineered tissue construction
- From: Chinese Journal of Tissue Engineering Research 2025;29(24):5179-5186
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Degenerative diseases caused by bone and muscle degeneration are major reasons for the decline in physical function and mobility,increased fragility fractures,and high mortality rates in the elderly,significantly affecting their health and quality of life.OBJECTIVE:To review the research progress in the mechanisms of muscle-bone interaction and the etiology,prevention,and treatment of related diseases.METHODS:CNKI,WanFang and PubMed databases were searched for relevant literature published from 2014 to 2024.The search terms were"muscle-bone crosstalk,musculoskeletal system,inter-tissue communication,myokines,osteokines,osteosarcopenia,sarcopenia,osteoporosis,bone regeneration,fibro-adipogenic progenitors"in Chinese and English.By reading the articles,we eliminated irrelevant,outdated,and poorly focused literature,and finally 94 articles were included for review.RESULTS AND CONCLUSION:Mechanical interaction,secretion factor interaction,and stem cell interaction between muscle and bone are crucial for the metabolism and regeneration regulation of the musculoskeletal system.Systemic interventions targeting biochemical signals of muscle factors(such as myostatin and irisin)and bone factors(such as nuclear factor-κB receptor-activating factor ligand and sclerostin)can improve the quality and function of skeletal muscle and bone,and have positive effects on fracture healing.In recent years,it has been found that related stem cells in the musculoskeletal system can interact,with the activation of muscle progenitor cells(such as fibro-adipogenic progenitors)having a significant impact on bone growth,repair,and regeneration.Research on the mechanisms of muscle-bone interaction can provide insights into the etiology,prevention,and treatment of related diseases.However,there are currently no effective clinical treatments for muscle-bone comorbidities,with most research still at the cellular and animal experiment stage.Therefore,extensive research is needed in the future to gradually move from experiments to clinical applications,developing more targeted therapies and drugs to better serve clinical needs.
