Relationship between AT1-AA levels in uterine fluid and the thickness of endometrium in infertile women with chronic endometritis
10.3760/cma.j.cn112141-20241205-00647
- VernacularTitle:慢性子宫内膜炎不孕症患者宫腔液中AT1-AA水平与子宫内膜厚度的关系
- Author:
Jiahui ZHOU
1
;
Guifang YANG
;
De SONG
;
Yinan ZHANG
;
Yao CHEN
;
Xuemin LI
;
Yana YU
;
Yuhui SHI
;
Wenli ZHU
;
Xiaoli YANG
Author Information
1. 太原市中心医院辅助生殖中心，太原 030000
- Publication Type:Journal Article
- Keywords:
Endometritis;
Infertility, female;
Uterus;
Body fluids;
Receptor, angiotensin, type 1;
Autoantibody;
Endometrium
- From:
Chinese Journal of Obstetrics and Gynecology
2025;60(7):520-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the level of angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA) in the uterine fluid and the thickness of endometrium in infertile women with chronic endometritis.Methods:A case-control study was conducted to select 122 patients who underwent hysteroscopy and endometrial tissue biopsy at Assisted Reproduction Center, Taiyuan Central Hospital due to infertility from March 2023 to January 2024 as the study subjects. According to the results of hysteroscopy and endometrial tissue biopsy, the patients were divided into 52 cases in the infertility group with normal endometrium (NE infertility group) and the chronic endometritis combined with infertility group (CE infertility group) with 70 cases. Enzyme-linked immunosorbent assay was used to detect the level of AT1-AA in uterine fluid of the two groups. General clinical data, AT1-AA absorbance value of uterine fluid and uterine related indexes of the two groups were analyzed, and the correlations between AT1-AA level and the variation of indexes were analyzed.Results:Gravidity (median: 1 vs 1; Z=7.029, P=0.030) and parity (median: 0 vs 0; Z=12.258, P=0.002) in CE infertility group were higher than those in NE infertility group. There was AT1-AA in the uterine fluid, and the level of AT1-AA in CE infertility group was significantly higher than that in NE infertility group (median: 2.07 vs 1.44; Z=3.099, P=0.029). The endometrial thickness of CE infertility group was lower than that of NE infertility group (median: 6.0 vs 7.0 mm; Z=-2.179, P=0.029), and there were no statistical differences in other indexes between the two groups (all P>0.05). Further correlation analysis showed that there were no correlation between the level of AT1-AA in uterine fluid and parity, endometrial thickness, gravidity in NE infertility group (all P>0.05). However, the level of AT1-AA in uterine fluid of CE infertility group was positively correlated with parity (Spearman′s r=0.339, P=0.004), and negatively correlated with endometrial thickness (Spearman′s r=-0.499, P<0.001), but not correlated with gravidity ( P>0.05). Conclusions:AT1-AA is present in the uterine fluid of infertile women. The elevated level of AT1-AA in uterine fluid of infertile women with CE is related to the thinning of the endometrium.
