Mitochondria:Potential Precise Diagnostic and Therapeutic Targets for Parkinson's Disease
10.13865/j.cnki.cjbmb.2024.12.1256
- VernacularTitle:线粒体:帕金森病潜在的精准诊疗靶点
- Author:
Shi-Qing FU
1
;
Chun-Yao WANG
;
Fang WANG
Author Information
1. 毕节医学高等专科学校基础医学系生理教研室,贵州毕节 551700;毕节市健康产业重点实验室,贵州毕节 551700
- Publication Type:Journal Article
- Keywords:
Parkinson's disease(PD);
neurons;
mitochondrial functional proteins;
mitochondrial dys-function
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(4):514-521
- CountryChina
- Language:Chinese
-
Abstract:
As an indispensable"energy factory"within cells,mitochondria efficiently convert chemical energy from food into ATP through oxidative phosphorylation,providing continuous energy support for va-rious cellular life activities.The functional homeostasis of mitochondria maintains the cell's energy sup-ply,redox balance,cell signaling,and metabolic regulation,thereby ensuring normal cell operation and the healthy survival of organisms.Processes such as mitophagy,mitochondrial fusion and fission,mito-chondrial transport,reactive oxygen species accumulation,and calcium signaling are involved in maintai-ning mitochondrial functional homeostasis.The degeneration of dopaminergic neurons in the striatum is the main pathological feature of Parkinson's Disease(PD).Dopaminergic neurons have unique polarized and extended structures with high bioenergetic demands,making them particularly susceptible to mito-chondrial dysfunction.When mitochondrial function is impaired,the energy supply to dopaminergic neu-rons is insufficient,leading to neuronal dysfunction and subsequently triggering a series of neurodegenera-tive diseases,including PD.The molecular basis of PD pathogenesis often involves abnormalities in pro-teins that maintain mitochondrial homeostasis.These proteins play crucial roles in sustaining mitochondri-al function,and any functional abnormalities or genetic mutations can lead to mitochondrial dysfunction,thereby inducing PD.This article provides a comprehensive review of recently reported abnormalities in proteins maintaining mitochondrial function and their association with the onset and progression of PD.The aim is to gain a deeper understanding of the functions of these proteins,their genetic mutations,and their relationship with the disease,providing valuable insights for the development of effective treatments and diagnostic biomarkers for PD.
