The Role of m6A Modification in the Pathogenesis of Neuropathic Pain:Explorations Based on Different Diseases and Pain Models
10.13865/j.cnki.cjbmb.2025.02.1471
- VernacularTitle:m6A修饰在神经病理性疼痛发病机制中的作用研究:基于不同疾病与疼痛模型的探索
- Author:
Yuan-Long DING
1
;
Xing-Nan LI
;
Jing LUO
Author Information
1. 云南省第一人民医院麻醉科,昆明 650032;昆明理工大学灵长类转化医学研究院;省部共建非人灵长类生物医学国家重点实验室,昆明 650500
- Publication Type:Journal Article
- Keywords:
neuropathic pain(NP);
N6-methyladenosine(m6A);
m6A methyltransferase;
m6A dem-ethylase;
m6A reading protein
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(4):505-513
- CountryChina
- Language:Chinese
-
Abstract:
Neuropathic pain(NP)is a type of chronic pain caused by damage or disease of the nervous system.It is mainly characterized by spontaneous pain,hyperalgesia,and allodynia,which seriously af-fect the quality of life of patients.The pathogenesis of NP is complex,involving abnormal regulation such as peripheral sensitization,central sensitization,ion channel changes,and glial cell activation.In recent years,the role of m6A in NP has attracted extensive attention.However,the research on the role of m6A modification in different diseases and pain models is still limited.Therefore,it is particularly important to clarify the role of m6A modification in different diseases and pain models.This article reviews the re-search progress on the role and mechanism of m6A methylation modification in the pathogenesis of NP in recent years,especially the role mechanism of the five classical m6A modification factors,METTL3,METTL14,FTO,ALKBH5 and YTHDF1,in mediating the formation of NP in different diseases and pain models,with the expectation of providing new insights and ideas for the drug development and pre-vention of NP from the perspective of m6A modification.
