A survey of the off-label use in patients with major mental disorders in a tertiary psychiatric hospital in 2017
10.3760/cma.j.issn.1006-7884.2019.03.003
- VernacularTitle:2017年某三甲精神疾病专科医院三种疾病住院患者超说明书用药现况调查
- Author:
Xinhu YANG
1
;
Tianle WANG
;
Weijian LIU
;
Ben CHEN
;
Yanling ZHOU
;
Chanjuan ZHANG
;
Jinqing HU
;
Haishan SHI
;
Chang QIU
;
Xiong HUANG
;
Ni FAN
;
Yuping NING
Author Information
1. 广州医科大学附属脑科医院(广州市惠爱医院)物质依赖科 510370
- Publication Type:Journal Article
- Keywords:
Psychotic disorders;
Hospitals,special;
Prospectuses;
Risk factor
- From:
Chinese Journal of Psychiatry
2019;52(3):181-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the status quo of the off-label use in patients with major mental disorders in a tertiary psychiatric hospital and to analyze its relevant risk factors,so as to provide the basis for establishing the off-label use norm.Methods The data of inpatients with major mental disorders (schizophrenia,bipolar disorder and depression) were collected from electronic medical records system in the Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital).The incidence and categories of off-label use were analyzed by descriptive analysis.The chi-square test and logistic regression analysis were used to analyze factors such as age,gender,diagnosis,the number of prescribed psychotropic drugs,physician title,etc.Results A total of 2 371 patients and 10 794 prescriptions were collected and analyzed.The incidence of off-label use was 80.43％ (1 907/2 371) and 42.46％ (4 583/10 794) in patients and prescriptions,respectively.The main categories and constituent ratio of off-label use were indications (89.16％,4 086/4 583),dosage (4.63％,212/4 583),population and age (0.31％,14/4 583),while there were 5.91％ (271/4 583) prescriptions contain 2 or more different categories.The off-label use was widespread among different types of psychotropic drugs,mental disorders and clinical departments.The risk factors were the number of prescribed psychotropic drugs (Wald=177.218,P＜0.01),the diagnosis of mental disorders (Wald=35.320,P＜0.01) and physician title (Wald=8.667,P=0.003).Conclusion Off-label use is common in patients in the tertiary psychiatric hospital,involving different kinds of psychotropic drugs,mental disorders and clinical departments.The primary category of off-label use is indications.
