Mechanisms of IGF-1 and Oxidative Stress in Polycystic Ovary Syndrome
10.3870/j.issn.1672-0741.25.03.019
- VernacularTitle:IGF-1与氧化应激在多囊卵巢综合征中的作用机制
- Author:
Qi ZHAO
1
;
Ping CHEN
;
Liping YANG
Author Information
1. 河南中医药大学第一附属医院妇产科,郑州 450000
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
oxidative stress;
insulin-like growth factor 1;
insulin resistance;
hyperan-drogenemia
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(5):750-755
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome(PCOS)is a common endocrine disorder closely associated with insulin resistance(IR)and hyperandrogenemia(HA).Oxidative stress has been closely linked to chronic metabolic diseases such as IR and diabetes,and is also considered one of the key factors in the pathogenesis and progression of PCOS.Under physiological conditions,insulin-like growth factor 1(IGF-1)plays a crucial role in regulating cellular proliferation,metabolic processes,and alleviating oxidative stress.However,in PCOS patients,an oxidative stress state is frequently observed,which interacts with IR and HA to stimulate elevated IGF-1 levels.This,in turn,exacerbates oxidative stress and inflammatory responses,ultimately worsening the patholog-ical state of PCOS.This review summarizes the molecular mechanisms underlying the roles of IGF-1 and oxidative stress in the onset and progression of PCOS,aiming to provide new insights into its pathophysiology and potential therapeutic strategies.
