Study on the Predictive Value of Serum Human Epididymis Protein 4 Level Measurement in Patients with Sj?gren's Syndrome for Renal Injury
10.3969/j.issn.1671-7414.2025.03.034
- VernacularTitle:干燥综合征患者血清人附睾蛋白4水平检测对肾损伤的预测价值研究
- Author:
Li CHEN
1
;
Yaqing LIU
1
;
Limin ZHANG
1
;
Yihua ZHU
1
;
Huiqun TIAN
1
Author Information
1. 宜昌市第二人民医院/三峡大学第二人民医院检验科,湖北 宜昌 443000
- Publication Type:Journal Article
- Keywords:
primary Sj?gren's syndrome;
human epididymis protein 4;
renal injury
- From:
Journal of Modern Laboratory Medicine
2025;40(3):183-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum human epididymis protein 4(HE4)levels in primary Sj?gren's syndrome(pSS)patients for renal injury.Methods A retrospective analysis of 77 pSS patients admitted to the Second People's Hospital of Yichang from September 2021 to August 2023 was performed,including 43 cases of renal injury group 34 instances of non-renal injury group,and 54 healthy physical examination subjects(HCs)as control group.Fasting peripheral venous blood(4ml)was collected to detect the serum levels of HE4,Cys-C,TNF-α,CR,C3,C4,immunoglobulin,Anti-SSA,Anti-SSB and other indicators,and analyzed the value of HE4 in the early diagnosis of kidney injury in pSS patients.Results Compared with HCs,the pSS patients had increased levels of HE4(120.02±103.86 pmol/L vs 57.5±16.52 pmol/L),Cys-C(1.30±0.81mg/L vs 0.87±014 mg/L),and the differences were statistically significant(t=4.382,3.860,all P<0.05).The serum levels of HE4,CR and TNF-α in the renal damage group were higher than those in the non-renal damage group,and the differences were statistically significant(t/χ2=2.552～4.371,all P<0.05).Pearson correlation analysis showed that,the levels of serum HE4,Cys-C,CR and TNF-α were all positively correlated with renal damage in pSS(r=0.287～0.546,all P<0.05).Logistic regression analysis showed that elevated serum HE4 level might be an independent risk factor for inducing renal damage in pSS(Wald χ2=11.932,P<0.05).Receiver operating characteristic(ROC)curve analysis showed that the best cut-offvalue of serum HE4 for the diagnosis of pSS renal damage was 70.46pmol/L,the maximum Youden index was 0.625,AUC(95%CI)=0.876(0.799～0.954).Conclusion The serum HE4 level in patients with pSS is positively correlated with renal injury and has predictive value for the occurrence of renal injury.
