Therapeutic Effects of Nanomaterials in Alzheimer's Disease by Regulating Its Pathogenic Mechanisms
10.13865/j.cnki.cjbmb.2025.01.1346
- VernacularTitle:纳米材料通过调控阿尔茨海默症的致病机制对其进行治疗的研究
- Author:
Kai-Li WANG
1
;
Tao WU
;
Chao-Xiu REN
Author Information
1. 北京石油化工学院新材料与化学工程学院,恩泽生物质精细化工北京市重点实验室,北京 102617
- Publication Type:Journal Article
- Keywords:
Alzheimer's diseases(AD);
nanomaterials;
amyloid protein(AP);
oxidative stress;
neu-roinflammation
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(4):533-540
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)has attracted widespread attention due to its extremely complex pathogenic mechanisms,multiple pathogenic factors,and its heavy burden on patients and the society.In recent years,several studies have revealed various pathogenic mechanisms of AD,and the AD treatments based on these mechanisms become research hotspot in nanomedicine.Nanomaterials with unique physi-cochemical properties show great potential in AD treatment.Nanomaterials possess good biocompatibility.Moreover,they can regulate and release therapeutic drugs continuously and steadily to ensure the ideal concentrations of drugs reach in the target site.Meanwhile,they can bind with the therapeutic targets precisely to treat AD.Therefore,the development of novel nanodrugs has become an important research area in AD treatment.This article reviews the main pathological features and pathogenic mechanisms of AD,including β-amyloid plaque aggregation,Tau protein hyperphosphorylation,oxidative stress,and neuroinflammation.Additionally,this review mainly discusses the therapeutic strategies of nanomaterials in clearing pathological proteins(such as β-amyloid and Tau proteins),inhibiting oxidative stress,and alleviating neuroinflammation.Finally,this review prospects the risks and challenges faced on current AD treatment strategies by nanomaterials,such as low drug delivery efficiency to the brain and potential side effects after treatment.We also provide suggestions for the future directions in this research field.This review aims to promote the clinical translation of nanomaterials in AD treatment by discussing the research status of this field.
