Factors affecting the effectiveness of high-frequency transcranial magnetic stimulation in the treatment of neuropathic pain following spinal cord injury
10.3760/cma.j.cn421666-20240828-00698
- VernacularTitle:高频重复经颅磁刺激治疗脊髓损伤后神经病理性疼痛疗效的影响因素分析
- Author:
Yixing LU
1
;
Xiaolong SUN
;
Xiao XI
;
Xiangbo WU
;
Tao HAN
;
Xinyu LIU
;
Qiaozhen LI
;
Guiqing CHENG
;
Chunqiu DAI
;
Ying LIANG
;
Hua YUAN
Author Information
1. 空军军医大学第一附属医院（西京医院）康复医学科，西安 710032
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
Neuropathic pain;
Transcranial magnetic stimulation
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(3):226-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the factors associated with the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of neuropathic pain (NP) following spinal cord injury (SCI).Methods:This was a retrospective study of 89 SCI survivors with NP receiving high-frequency rTMS. Those with a ≥30% reduction in their Numeric Rating Scales (NRS) scores after 2 weeks of treatment were termed Responders ( n=36), with the others classified as non-responders ( n=53). Demographic data (gender, education level, age), SCI characteristics (injury etiology, injury severity, neurological injury level, injury duration), NP characteristics (pain type, pain intensity, analgesic use), functional assessment (Modified Ashworth Scale score, Spinal Cord Independence Measure score, Modified Barthel Index score, American Spinal Injury Association motor/sensory score) were collected. Least absolute shrinkage and selection operator (LASSO) regression was used for variable selection, followed by binary logistic regression to identify factors associated with treatment efficacy. Results:Among the 89 patients, 36 (40.4%) were Responders to high-frequency rTMS. Binary logistic regression revealed that those with a cervical spinal cord injury and/or spasticity and women were more likely to respond to high-frequency rTMS.Conclusions:Female gender, cervical spinal cord injury, and spasticity are independent factors predicting rTMS efficacy in treating SCI, with spasticity demonstrating the strongest association.
