Hemoglobin levels can predict cognitive impairment among elderly stroke survivors
10.3760/cma.j.cn421666-20240510-00359
- VernacularTitle:血红蛋白水平与老年卒中患者认知障碍的相关性研究及预测价值分析
- Author:
Qingfu MENG
1
;
Juanjuan HUANG
;
Yan LU
;
Maofang ZHU
;
Mingyue ZHU
Author Information
1. 南京市栖霞区医院康复医学科、江苏省人民医院栖霞分院康复医学科，南京 210046
- Publication Type:Journal Article
- Keywords:
Elderly;
Stroke;
Cognitive impairment;
Hemoglobin;
Mini-mental State Examination
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(3):237-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectively seek any correlation between hemoglobin (Hb) levels and post-stroke cognitive impairment (PSCI), and to explore the value of Hb levels in PSCI diagnosis and prediction.Methods:The Mini-mental State Examination (MMSE) was used to sort elderly persons who had suffered a first stroke into a PSCI group showing cognitive impairment and a PSNCI group which was not cognitively impaired. Healthy counterparts undergoing physical examinations were selected into a healthy group. Everyone′s white blood cell count (WBC), neutrophil count (NC), lymphocyte count (LC), monocyte count (MONO), platelet count (PLT) and Hb, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were recorded. Monocyte to high density lipoprotein cholesterol ratios (MHRs), neutrophil to lymphocyte ratios (NLRs), and platelet to lymphocyte ratios (PLRs) were calculated. The differences among the three groups were compared seeking to identify risk factors predicting PSCI.Results:There were no significant differences in age, gender, WBC, MONO, PLT, TG or MHR among the three groups, on average. But there were significant differences in NC, LC, Hb, TC, HDL-C, LDL-C, NLR and PLR. Spearman correlation analysis showed that NC, NLR and PLR were negatively correlated with the average MMSE score, while LC, Hb, TC, HDL-C and LDL-C were positively correlated with it. Logistic regression analysis showed that a low level of Hb was an independent risk factor for PSCI for the elderly stroke survivors. The area under the receiver operating characteristics curve (AUC) for Hb was 0.794 for predicting PSCI in elderly stroke patients, with a maximum Youden index of 0.496. The critical value of Hb was estimated as 138.5g/L.Conclusions:Hb levels can significantly predict the cognitive functioning of elderly stroke survivors. An Hb level below 138.5g/L is an independent risk factor for PSCI, while higher Hb levels may indicate cognitive benefits.
