CXCL8 expression and its clinical significance in cervical cancer tissues
10.12007/j.issn.0258-4646.2025.10.009
- VernacularTitle:CXCL8在宫颈癌组织中的表达及临床意义
- Author:
Hua ZHANG
1
;
Ibibulla NURBIA
;
Pengfei LU
;
Chunli JIA
;
Xuanxuan PEI
;
Yongxing BAO
Author Information
1. 新疆医科大学第一附属医院肿瘤中心,省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
cervical cancer;
CXCL8;
bioinformatics;
prognosis
- From:
Journal of China Medical University
2025;54(10):914-918,925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the expression of CXCL8 in cervical cancer and its association with clinicopathological features and therapeutic efficacy of patients.Methods Bioinformatic analysis was performed using The Cancer Genome Atlas and Genotype-Tissue Expression databases to compare CXCL8 expression between cervical cancer and normal tissues.R software(version 4.4.0)was used for data analysis,with the timeROC package applied to construct time-dependent receiver operating characteristic(ROC)curves for evalua-ting the prognostic predictive efficacy of CXCL8.The survival package with the survfit function was used to compare survival differences between CXCL8 high-and low-expression groups.Clinical data and tissue specimens were collected from 94 patients with cervical squa-mous cell cancer treated at The First Affiliated Hospital of Xinjiang Medical University between January 2017 and December 2021.Immu-nohistochemical staining was used to detect CXCL8 expression levels and analyze its correlation with clinicopathological characteristics,therapeutic efficacy,and prognosis.Results Bioinformatic analysis showed that CXCL8 was highly expressed in cervical cancer tissues than in normal tissues(P＜0.05).Time-dependent ROC curves and survival analyses showed that patients with high CXCL8 expression had significantly shorter overall survival than those with low CXCL8 expression(P＜0.001).Immunohistochemical results showed that CXCL8 expression in cervical cancer tissues was significantly higher than that in adjacent tissues(P＜0.000 1).Clinical correlation analy-sis revealed that CXCL8 expression levels were associated with treatment regimen(P＜0.001)and short-term therapeutic efficacy(P=0.017).Compared to the low-expression group,the high-expression group showed a significantly lower therapeutic efficacy and shorter overall survival(P＜0.05).Conclusion CXCL8 is highly expressed in cervical cancer tissues,and patients with high CXCL8 expression have poor prognosis.Thus,CXCL8 may be an effective target for assessing the prognosis and clinical treatment of cervical cancer.
