Detection of type Ⅳ collagen A2 and integrin β3 expression in prostate cancer and their clinical characteristics
10.3760/cma.j.issn.1009-6906.2019.02.013
- VernacularTitle:COL4A2和ITGB3在前列腺癌组织中的表达及其与临床特征的关系
- Author:
Jiaming SU
1
;
Zhangcheng LIU
;
Dongbo YUAN
;
Wei WANG
;
Yongqiang ZHANG
;
Jianguo ZHU
;
Zhaolin SUN
Author Information
1. 563000贵州省遵义,遵义医学院;贵州省人民医院泌尿外科
- Publication Type:Journal Article
- Keywords:
Prostate cancer;
Type Ⅳ collagen A2;
Integrin β3;
Tumor microenvironment;
Invasion;
Metastasis
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2019;26(2):130-133,138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of type Ⅳ collagen A2 (COL4A2) of extracellular matrix and integrin β3 (ITGB3) in prostate cancer (PC) of tumor microenvironment.Methods The specimens were collected and immunohistochemical staining (IHC) was used to detect the expression levels of COL4A2 and ITGB3 in human prostate cancer tissues and corresponding adjacent tissues.The expression levels were analyzed and clinically diagnosed in PC patients.The correlation between the eigenlogical features was further analyzed by Pearson statistical method.Results The expression levels of COL4A2 and ITGB3 in prostate cancer tissues were significantly higher than those in adjacent tissues [immunoreactive score (IRS):COL4A2:prostate cancer tissues =4.39 ± 1.16,adjacent normal tissues =3.02 ± 1.20 (P ＜ 0.01);ITGB3:prostate cancer tissue =5.46 ± 0.99,adjacent normal tissues =3.85 ± 0.96 (P＜0.01)],both expressions were consistent with the pathological stage of PC (P ＜0.05).The Gleason scores increased(P ＜ 0.05) and the expression of both was positively correlated in prostate cancer (Pearson r =0.206,P ＜ 0.05).Conclusion COL4A2 and ITGB3 were up-regulated in prostate cancer and were associated with the staging of tumor tissues.The later the staging,the higher the expression of both,suggesting that they might play an important role in the malignant progression of PCa.Csmbined defection might help to identify Helps to judge the degree of malignancy,invasion and metastasis of PC.
