Transcranial magnetic stimulation can improve the cognition and ability in the activities of daily living of persons with cerebral small vessel disease
10.3760/cma.j.cn421666-20240328-00216
- VernacularTitle:重复经颅磁刺激对脑小血管病患者认知功能和日常生活活动能力的影响
- Author:
Xue ZHENG
1
;
Tiantian WANG
;
Tong SU
;
Jiaming XU
;
Bing FU
;
Min LI
Author Information
1. 连云港市第二人民医院神经内科，连云港 222023
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Transcranial magnetic stimulation;
Cognition;
Activities of daily living
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(1):31-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of repetitive transcranial magnetic stimulation (rTMS) on the cognition and ability in the activities of daily living (ADL) of persons with cerebral small vessel disease.Methods:A total of 71 patients with cognitive impairment due to cerebral small vessel disease were randomly divided into a control group ( n=35) and a treatment group ( n=36). The treatment group was further divided into a group with mild cognitive impairment (a score of 21 to 26 on the mini-mental state exam, n=23) and a moderate cognitive impairment group (scoring 10 to 20, n=13). The treatment groups received 10Hz rTMS, while the control group received sham rTMS. Before and after 90 days of treatment, all were assessed using the mini-mental state examination (MMSE) and the cognitive subscale of the vascular dementia assessment scale (VaDAS-cog). Ability in the activities of daily living was quantified using the Barthel Index (BI). Results:After treatment, significantly increased MMSE and BI scores, but significantly decreased VaDAS-cog scores were observed in both groups. At that point the treatment group showed a significantly higher average post-treatment MMSE score (25.61±2.94) and BI score (80.00±7.85), but a significantly lower average VaDAS-cog score (44.06±3.41) than the control group. The average MMSE scores were not significantly different between the mild and moderate cognitive impairment subgroups. No severe adverse reactions were observed during the rTMS treatment.Conclusions:The 10Hz rTMS can effectively improve the cognition and daily living ability of persons with cerebral small vessel disease.
