Correlation of Polymorphisms at ICAM-1 Gene rs3093030 and rs5498 with hs-CRP Expression and Analysis of Disease Susceptibility in Peripheral Blood of Patients with T2DM Complicated Hypertension in Guilin,Guangxi Province
10.3969/j.issn.1671-7414.2025.03.014
- VernacularTitle:广西桂林地区T2DM合并高血压患者外周血ICAM-1基因rs3093030和rs5498位点多态性与hs-CRP表达相关性以及对疾病易感性分析
- Author:
Chao ZUO
1
;
Yi LIU
;
Feng WANG
;
Yu WANG
;
Huasong GONG
;
Yongchao QIAO
Author Information
1. 桂林医学院附属医院 检验科,广西 桂林 541001
- Publication Type:Journal Article
- Keywords:
intercellular adhesion molecule-1;
polymorphism;
type 2 diabetes mellitus complicated hypertension
- From:
Journal of Modern Laboratory Medicine
2025;40(3):75-79,90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphisms at the rs3093030 and rs5498 loci of the intercellular adhesion molecule-1(ICAM-1)gene in combination with high sensitive C-reactive protein(hs-CRP)and susceptibility to type 2 diabetes mellitus complicated with HTN(T2MH)susceptibility.Methods 200 newly diagnosed T2DM patients,175 T2MH patients and 200 healthy controls from Affiliated Hospital of Guilin Medical University between September 2021 and January 2022.Single nucleotide polymorphisms(SNP)-scan high-throughput technology was used to detect the genotyping of serum rs3093030 and rs5498 polymorphisms in the study subjects and to detect hs-CRP levels in peripheral plasma to analysed and explore the correlation between them and the development of T2MH.Results The peripheral blood hs-CRP expression level of patients in the T2MH group[2.65(1.18,6.50)mg/L]was significantly higher than that in the T2DM group[1.82(0.80,4.48)mg/L]and healthy controls[1.02(0.54,2.29)mg/L],and the differences were statistically significant(Z=-2.729,-7.132,all P<0.001).After population classification by genotype,it was found that compared with healthy controls,rs3093030 CC(Z=-3.912,-5.800),rs5498 AA(Z=-3.293,-4.944)and AG(Z=-3.275,-4.872)genotypes had significantly higher hs-CRP levels.The peripheral blood hs-CRP levels of patients with rs3093030 CT genotype in the T2MH group were significantly higher than that of healthy controls(Z=-3.987),and the differences was statistically significant(all P<0.001),respectively.Meanwhile,regression analysis showed that HS-CRP was a risk factor for both T2MH group and healthy control group(OR=1.181,95%CI=1.095～1.274,P<0.001).Conclusion There is a correlation between ICAM-1 gene rs3093030 and rs5498 polymorphisms combined with hs-CRP levels in peripheral blood and the pathogenesis of T2MH patients.
