Deficits of perceived spatial separation induced prepulse inhibition in patients with first?episode schizophrenia
10.3760/cma.j.issn.1006?7884.2019.06.005
- VernacularTitle:首次发病精神分裂症患者知觉空间分离下的前脉冲抑制缺陷
- Author:
Ningbo YANG
1
;
Qing TIAN
;
Zhen MAO
;
Yu FAN
;
Qijing BO
;
Ming LEI
;
Liang LI
;
Chuanyue WANG
Author Information
1. 河南科技大学第一附属医院精神心理科,洛阳,471003
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Logistic models;
Prepulse inhibition;
Perceived spatial separation;
Attentional regulation
- From:
Chinese Journal of Psychiatry
2019;52(6):387-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the discrimination of first?episode schizophrenia patients and healthy people using a perceived spatial separation induced pre?pulse inhibition (PSS?PPI). Methods A total of 42 patients with first?episode schizophrenia and 38 healthy controls matched with gender, age, and education level were included. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychopathological symptoms of the patients, all subjects underwent modified paradigm of prepulse inhibition (PPI) measurement. PPI of the two groups were analyzed via the variance and post hoc test. Logistic regression analysis for modified PPI as predictor to differentiate patients from healthy controls. Results There were differences in PSS?PPI between the two groups during 60 ms and 120 ms interstimulus interval (27.6 (14.2, 31.7) vs . 37.9 (26.5, 60.4), Z=-4.04, P<0.01; 28.8 (3.2, 39.6) vs . 40.4 (27.4, 53.0), Z=-3.15, P<0.01), and the effect size (Cohen’d) was 0.91 and 0.70, respectively. Logistic regression analysis with PSS?PPI as the classification predictor showed that diagnosis accuracy of PSS?PPI (60 ms and 120 ms) was 81.0% and 73.5% respectively. Conclusion There is a statistically significant deficit of PSS-PPI in patients compared with healthy controls with moderate to large effect sizes.
