Analyzing hemoglobin activation at prefrontal cortex for suicidal behavior and suicidal ideation in depressed patients
10.3760/cma.j.issn.1006?7884.2019.06.008
- VernacularTitle:伴自杀行为和自杀观念抑郁症患者前额叶近红外光图谱分析
- Author:
Xiaoqian ZHANG
1
;
Chenyu SHEN
;
Guifang CHEN
;
Xiaomin LIU
;
Kun FENG
;
Gaoxiang SUN
;
Pozi LIU
Author Information
1. 清华大学玉泉医院精神卫生科,北京,100040
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Prefrontal cortex;
Spectroscopy,near?infrared;
Verbal fluency task;
Suicide
- From:
Chinese Journal of Psychiatry
2019;52(6):403-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of prefrontal cortex activation by near?infrared spectroscopy (NIRS) in depressed patients who also had suicide ideation or committed suicide. Methods Total 23 patients who suffered major depression disorder (MDD) complicated with suicide behavior (suicide behavior group), 28 MDD patients bearing suicide ideation without behavior (suicide ideation group), and 26 healthy controls, matched with the gender, age, and education, were tested by category verbal fluency task (VFT). During the task, 52?channel FOIRE?3000 of Shimadzu was used to collect the relative concentration of oxygenate hemoglobin (Oxy?Hb) from all three groups. Results There was no significant difference between suicide behavior group and suicide idea group in their VFT performance (F=11.196, P>0.05), which however were both lower than the healthy control group (P<0.05);the Oxy?Hb exchange of the bilateral orbitofrontal cortex and bilateral dorsolateral prefrontal cortex in suicide behavior group and the suicide idea group were significantly lower than the healthy control group (P<0.05). Conclusion The activity of the prefrontal cortex in MDD patients who had suicide ideation or committed suicide is significantly lower with the most prominent change found in bilateral orbitofrontal cortex and bilateral dorsolateral prefrontal cortex.
