Effect of liposomal bupivacaine transversus abdominis plane block on postoperative quality of recovery in patients undergoing laparoscopic colorectal surgery
10.3760/cma.j.cn131073-20241107-00708
- VernacularTitle:布比卡因脂质体TAPB对腹腔镜结直肠手术患者术后恢复质量的影响
- Author:
Haitao WANG
1
;
Huijuan LI
1
;
Yingying ZHAO
1
;
Yunli HUANG
1
;
Qiong XUE
1
Author Information
1. 郑州大学第一附属医院麻醉与围手术期及疼痛医学部，郑州 450052
- Publication Type:Journal Article
- Keywords:
Bupivacaine;
Liposomes;
Nerve block;
Colorectal surgery;
Laparoscopy
- From:
Chinese Journal of Anesthesiology
2025;45(7):823-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of liposomal bupivacaine transversus abdominis plane block (TAPB) on the postoperative quality of recovery in patients undergoing laparoscopic colorectal surgery.Methods:In this randomized controlled trial, 100 patients of either sex, aged 18-75 yr, with a body mass index of 18.5-29.9 kg/m 2, of American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ, scheduled for elective laparoscopic colorectal surgery, were allocated into 2 groups ( n=50 each) in a 1∶1 ratio using a random number table method: liposomal bupivacaine TAPB group (LB group) and hydrochloric bupivacaine TAPB group (HB group). Before anesthesia induction, ultrasound-guided bilateral TAPB was performed, liposomal bupivacaine (266 mg) 40 ml (20 ml per side) was injected in LB group, and bupivacaine hydrochloride (100 mg) 40 ml (20 ml per side) was injected in HB group. When pain scores at rest ≥4 within 72 h after the end of surgery, patient-controlled intravenous analgesia with morphine injectio 3 mg was used. The Quality of Recovery-15 scale score was recorded at 24, 48 and 72 h postoperatively. The time to first rescue analgesia and total consumption of morphine within 72 h after operation were recorded. The occurrence of adverse reactions, including nausea and vomiting, urinary retention, pruritus, local anesthetic toxicity and hematoma at the puncture site, was recorded within 72 h after surgery. Results:Compared to HB group, Quality of Recovery-15 scale scores were significantly increased at 24, 48 and 72 h postoperatively, the time to first rescue analgesia was prolonged, the consumption of morphine was reduced within 72 h postoperatively, and the incidence of postoperative nausea and vomiting was decreased( P<0.05), and no statistically significant changes in the incidence of urinary retention or pruritus were found within 72 h postoperatively in LB group ( P>0.05). No local anesthetic toxicity or hematoma at the puncture site occurred in either group. Conclusions:Liposomal bupivacaine TAPB can improve the postoperative quality of recovery in the patients undergoing laparoscopic radical resection for colorectal cancer.
