Efficacy and safety of intravenous thrombolysis with tenecteplase in treatment of capsular warning syndrome
10.3969/j.issn.1009-0126.2025.08.017
- VernacularTitle:替奈普酶静脉溶栓对内囊预警综合征患者的疗效及安全性研究
- Author:
Tengfei ZHANG
1
;
Shengjie HU
;
Shengqi FU
;
Ying ZHANG
;
Lili ZHU
;
Liang SONG
;
Sisen ZHANG
Author Information
1. 450003 郑州,河南中医药大学第五临床医学院(郑州人民医院)急诊医学科
- Publication Type:Journal Article
- Keywords:
internal capsule;
tenecteplase;
prognosis;
ischemic attack,transient
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(8):1056-1060
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of intravenous thrombolysis with tenecteplase in the treatment of CWS.Methods A prospective study was conducted on 136 CWS patients consecutively admitted in Department of Neurology of Zhengzhou People's Hospital from March 2019 to March 2024.They were randomly divided into a tenecteplase group(67 cases)and a control group(69 cases).NIHSS was used to evaluate the recovery of neurological function after treatment.mRS was employed to assess long-term prognosis.Results Significantly larger proportion of white matter lesions and higher baseline SBP level were observed in the tenecteplase group than the control group(P＜0.05).The tenecteplase group obtained obviously greater ratio of overall recovery than the control group,with notably lower NIHSS score,incidence of new CWS attacks and proportion of new acute cerebral infarction at 24 and 72 h and 7 d after treat-ment(P＜0.05,P＜0.01).Moreover,the proportion of mRS score of 0-2 was notably greater,while that of the score of 3-6 was lower in the tenecteplase group than the Control group(P＜0.05).Intravenous thrombolysis with tenecteplase was an influencing factors for 90-day mRS score of 0-2 and of 3-6 in the CWS patients(OR=0.264,95％CI:0.089-0.813;OR=4.144,95％CI:1.184-14.506,P＜0.05).Conclusion Intravenous thrombolysis with tenecteplase for CWS significantly improves the proportion of patients with good prognosis.
