Research advances in neuro-immune mechanisms of chronic pain
10.13431/j.cnki.immunol.j.20250095
- VernacularTitle:神经-免疫机制在慢性疼痛中的研究进展
- Author:
Hong YANG
1
;
Xianli ZHOU
1
;
Jingming HOU
1
Author Information
1. 陆军军医大学第一附属医院康复科,重庆 400038
- Publication Type:Journal Article
- Keywords:
chronic pain;
neuro-immune mechanisms;
neuroinflammation;
pain sensitization;
pain matrix
- From:
Immunological Journal
2025;41(9):679-688
- CountryChina
- Language:Chinese
-
Abstract:
Chronic pain impairs functions across multiple dimensions,including physical,psychological,and social well-being.The neuro-immune mechanisms involve complex interactions between the immune system and nerve fibers at one or multiple levels of the peripheral or central nervous system.In recent years,research on the neuro-immune circuit mechanisms underlying the generation,transmission,modulation,and integration of chronic pain has advanced rapidly.However,the overall interactive dynamics of neuro-immune mechanisms remain unclear.This article systematically reviews recent advances in the neuro-immune mechanisms of chronic pain,elucidating the cascading transformation from peripheral to central sensitization.These findings provide a theoretical basis for a deeper understanding of the overall pathophysiological basis of pain chronicity and the exploration of effective clinical strategies.
