Correlation between the Location of Adult Peptic Ulcers and Helicobacter Pylori Infection and Antibody Typing
10.3969/j.issn.1671-7414.2025.06.034
- VernacularTitle:成人消化道溃疡发生部位与幽门螺杆菌感染及抗体分型相关性研究
- Author:
Quanshuang LI
1
;
Yi SHI
;
Kun TAN
;
Liangwen HAO
;
Shibao LI
Author Information
1. 徐州医科大学医学技术学院,江苏 徐州 221004;徐州市中心医院,江苏 徐州 221006;徐州市医学科学研究所,江苏 徐州 221006
- Publication Type:Journal Article
- Keywords:
peptic ulcer;
Helicobacter pylori(Hp);
antibody typing
- From:
Journal of Modern Laboratory Medicine
2025;40(6):185-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the location of adult peptic ulcers and Helicobacter pylori(Hp)infection and antibody typing,as well as its clinical significance.Methods A retrospective analysis was conducted on the serum Hp antibody typing results of adult patients 850 cases with peptic ulcers at Xuzhou Central Hospital from 2017 to 2024.According to the location of ulcers:duodenal ulcer group(DU group,n=429),gastric ulcer group(GU group,n=291)and ulcerative colitis group(UC group,n=130)were divided into three groups,and the relationship between ulcer location and Hp immunophenotyping was analyzed.The test results of 232 adult health examinees were used as the control group.Results The overall Hp infection rate in peptic ulcers patients was 79.76%(678/850),mainly with high virulence type I,with an rate of 62.71%(533/850),and type II was 17.06%(145/850).The Hp infection rates in the DU group,GU group,UC group and control groups were 86.48%(371/429),79.04%(230/291),59.23%(77/130)and 56.47%(131/232)respectively.The infection rates of type I were 72.96%,57.73%,40.00%and 47.41%,respectively.The infection rates of type II were 13.52%,21.31%,19.23%and 9.05%,respectively.The total infection rate,type I infection rate and type II infection rate of Hp were compared among the DU group,GU group,UC group and control group,and the differences were all statistically significant(χ2=91.838,67.169,17.647,all P<0.05).Compared with the UC group,the overall infection rate and type I infection rate of Hp in the DU group were the highest,followed by the GU group,and the differences were statistically significant(χ2=11.324～47.800,all P<0.05).However,the overall infection rate and the infection rate of type I were compared between the UC group and the control group,and the differences were not statistically significant(χ2=0.261,1.852,all P>0.05).The infection rate of type Ⅱ in GU group and UC group was significantly higher than that in controls groups,and the differences were statistically significant(χ2=14.518,7.782,all P<0.05).In addition,the positive rate of dual antibodies against CagA+VacA in the four groups was significantly higher than that of single antibody against CagA,VacA,and the differences were statistically significant(χ2=7.538～407.569,all P<0.05).Conclusion Adult patients with peptic ulcers are mainly infected with Hp type I strains,and the infection rate of type I strains is the highest in the DU group,followed by GU,while the infection rate of type I strains in UC is the lowest.UC is closely related to type II strain infection,and the infection rate is similar to that of GU patients.
