Effects of hyperbaric oxygen on serum sICAM-1 and S100B proteins in neonatal hypoxic ischemic encephalopathy
10.3760/cma.j.issn.1009-6906.2019.05.003
- VernacularTitle:高压氧对缺氧缺血性脑病新生儿血清sICAM-1及S100 B蛋白表达的影响
- Author:
Yanhua TIAN
1
;
Chunxia LONG
;
Shulin CUI
;
Nan XU
Author Information
1. 郑州煤炭工业集团有限责任公司总医院儿科神经内科, 郑州,452371
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Hypoxic ischemic encephalopathy;
Intercellular adhesion molecule 1;
S100B protein
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2019;26(5):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperbaric oxygen ( HBO) on serum intercellular adhesion molecule 1 (sICAM-1) and S100B proteins in the newborns with hypoxic ischemic encephalopathy ( HIE ) . Methods Sixty-two HIE newborns admitted to the hospital from May 2016 to January 2019 were selected as research subjects. According to the random cluster method, they were divided into the observation group and the control group, each consisting of 31 patients. The control group was given routine treatment, while the observation group received HBO in addition to the treatment received by the control group. Ten days after treatment, the levels of NBNA, nerve reflex and consciousness recovery time, sICAM-1, S100B protein expression and adverse reactions were compared between the patients of the 2 groups. Results Ten days after treatment, the NBNA scores of the 2 groups were all significantly higher than those before treatment. The NBNA scores of the observation group (30. 18 ± 5. 04) was obviously higher than those of the control group (24. 59 ± 5.14), with statistical significance (P < 0. 05). Nerve reflex and consciousness recovery time of the observationgroup[(3.88±1.23),(2.45±0.94)d] wereallsignificantlyshorterthanthoseofthecontrol group [(5. 69 ± 1. 37),(4. 17 ± 1. 13)d], also with statistical significance (P<0. 05). The expression levels of sICAM-1 and S100B in the patients of the 2 groups all decreased obviously as compared with those before treatment, and the levels of the observation group after treatment were evidently shorter than those of the control group, also with statistical significance (P<0. 05). During the course of treatment, total rate of adverse reactions in the observation group was higher (12. 9％) than that of the control group (9. 7％), but without statistical significance (P>0. 05). Conclusion HBO could improve the therapeutic effects on neonatal hypoxic ischemic encephalopathy and decrease the expression levels of SICAM-1 and S100B proteins.
