A Case of Severe Liver Dysfunction Caused by Pentoxifylline Injection

VernacularTitle:己酮可可碱注射液致严重肝功能异常1例
Author: Erxia SHI ¹ ; Laiyun YUN ; Zhongyan ZHOU ; Zhimin JIN ; Hua ZHEN
Author Information

1. 呼和浩特市第一医院药剂科,呼和浩特 010030
Publication Type:Journal Article
Keywords: Pentoxifylline injection; Abnormal liver function; Adverse drug reaction(ADR)
From: Herald of Medicine 2025;44(5):811-813
CountryChina
Language:Chinese
Abstract: A male patient,51 years old,was diagnosed as follows:① type 2 diabetes mellitus;② grade 2 hypertension(extremely high risk).To improve circulation,the patient was administered pentoxifylline injection 0.2 g mixed with 250 mL of 0.9％sodium chloride injection via an intravenous drip,once daily(qd).After 4 days of treatment,liver function tests showed the following results:alanine aminotransferase(ALT)at 2 390.80 U·L-1,aspartate aminotransferase(AST)at 948.28 U·L-1,and gamma-glutamyltransferase(GGT)at 517.81 U·L-1.It was highly probable that pentoxifylline caused abnormally elevated liver enzymes,with a clear drug-related association.After discontinuing pentoxifylline injection and initiating liver-protecting and en-zyme-lowering treatment,the liver function indicators gradually improved.Enhanced monitoring during the clinical use of pentoxi-fylline is essential to ensure patient safety.