Study on the Correlation between Hand Grip Strength-baseed Cachexia Index and All-Cause Mortality in A Population with Abnormal Liver Function Based on NHANES 2011～2014 Data
10.3969/j.issn.1671-7414.2025.06.025
- VernacularTitle:基于NHANES 2011～2014数据分析握力相关恶病质指数与肝功能异常人群全因死亡相关性研究
- Author:
Yujiao PENG
1
;
Jingjing HUANG
1
;
Yingsheng WU
1
;
Lu LU
1
;
Huanlin CHENG
1
;
Yuanqin DU
1
Author Information
1. 广西中医药大学第一附属医院脾胃肝病科,南宁 530000
- Publication Type:Journal Article
- Keywords:
hand grip strength(HGS)-based cachexia index(H-CXI);
all-cause mortality;
national health and nutrition examination survey(NHANES);
abnormal liver function
- From:
Journal of Modern Laboratory Medicine
2025;40(6):137-141,170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the level of hand grip strength(HGS)-based cachexia index(H-CXI)and all-cause mortality in a population with abnormal liver function.Methods The study was based on the America National Health and Nutrition Examination Survey(NHANES)data from 2011～2014,which included 2 752 cases of people with abnormal liver function and followed up until December 31,2019,using Kaplan-Meier survival analysis and COX regression modeling to assess the relationship between H-CXI levels and all-cause mortality,and restricted cubic spline analysis to explore the nonlinear relationship.Results There were 244 all-cause deaths during a mean follow-up time of 82.70±3.86 months.H-CXI was ana-lyzed as a categorical variable(quartiles),and Cox regression analyses showed that in model 2,the risk of all-cause mortality was reduced in groups Q2,Q3 and Q4 compared with group Q1(HR=0.41,95%CI:0.21～0.82,P=0.012 1;HR=0.34,95%CI:0.16～0.69,P=0.003 1;HR=0.24,95%CI:0.09～0.67,P=0.006 3).Subgroup analyses revealed an interaction between stroke and all-cause mortality,and restricted cubic spline revealed a nonlinear relationship between H-CXI levels and all-cause mortality.Con-clusion H-CXI levels are negatively associated with the risk of all-cause mortality in people with abnormal liver function,and attention to H-CXI levels is needed in clinical practice to prevent adverse health outcomes.
