Effect of smoking on sedative potency of remimazolam combined with alfentanil in patients undergoing painless gastroscopy
10.3760/cma.j.cn131073-20240514-00115
- VernacularTitle:吸烟因素对胃镜检查术患者复合阿芬太尼时瑞马唑仑镇静效力的影响
- Author:
Jin HUANG
1
;
Jiashuo ZHANG
;
Shichang LI
;
Yanan HAN
;
Shengyu WANG
;
Yan LIU
;
Hongze JIA
;
Hui WU
;
Xianbing GOU
;
Chunguang WANG
Author Information
1. 保定市第一中心医院麻醉科，保定 071000
- Publication Type:Journal Article
- Keywords:
Smoking;
Benzodiazepines;
Alfentanyl;
Gastroscopy;
Dose-effect relationship, drug
- From:
Chinese Journal of Anesthesiology
2025;45(1):77-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of smoking on the sedative potency of remimazolam combined with alfentanil in patients undergoing painless gastroscopy.Methods:This was a prospecctive single-center study. American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ male patients, aged 30-75 yr, with a body mass index of 18-28 kg/m 2, undergoing elective painless gastroscopy at Baoding First Central Hospital from October to December 2023, were divided into non-smoking group, mild smoking group (smoking index≤200), moderate smoking group (200 1 after 3 min of remimazolam injection or development of bucking, swallowing, body movement and other responses that affected operations during insertion of the endoscope. Results:A total of 85 patients were finally included, with 21 in non-smoking group, 21 in mild smoking group, 20 in moderate smoking group and 23 in heavy smoking group. The ED 50 of remimazolam was significantly higher in smoking groups than in non-smoking group ( P<0.05). The ED 50 of remimazolam gradually increased in mild, moderate and heavy smoking groups ( P<0.05). Conclusions:Smoking can decrease the sedative potency of remimazolam when combined with alfentanil in patients undergoing painless gastroscopy.
