Research progress on ferroptosis of placental cells in recurrent spontaneous abortion
10.3969/j.issn.1674-8115.2025.10.014
- VernacularTitle:复发性流产中胎盘细胞铁死亡的研究进展
- Author:
Guanghui LI
1
;
Xiaoling FENG
Author Information
1. 黑龙江中医药大学研究生院,哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
recurrent spontaneous abortion;
placenta;
ferroptosis;
trophoblast cell;
decidualization;
angiogenesis
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2025;45(10):1383-1389
- CountryChina
- Language:Chinese
-
Abstract:
Recurrent spontaneous abortion(RSA)is a pregnancy complication with a complex etiology that seriously threatens the fertility and physical and mental health of women of childbearing age.As the main component of the maternal-fetal interface,the placenta plays a central role in maternal and fetal health during pregnancy,and its dysfunction is closely associated with the development of RSA.Iron homeostasis is essential for supporting maternal needs,placental function,and fetal development.In recent years,ferroptosis,a novel form of cell death triggered by iron overload and the accumulation of lipid peroxides,has garnered increasing attention regarding its regulatory mechanisms in the physiological and pathological processes of the female reproductive system.Ferroptosis has been confirmed to correlate with placental pathology and to influence the pathogenesis of RSA.The placenta plays a crucial role in regulating iron transport.This paper systematically reviewed the mechanisms of ferroptosis in placental cells and its involvement in the pathogenesis of RSA by affecting trophoblast cell function,causing decidualization disorders,inducing angiogenesis defects,and the potential of ferroptosis-related molecules in the treatment of RSA was analyzed,with the aim of providing research directions for improving the pregnancy outcomes in patients with RSA.
