The orbitofrontal gyrus-cerebellum connections in obsessive compulsive disorder
10.3760/cma.j.issn.1006-7884.2019.04.005
- VernacularTitle:强迫症眶额叶-小脑连接的相关分析
- Author:
Qingjiang ZHAO
1
;
Haisan ZHANG
;
Bi WANG
;
Nan YAO
;
Xiaoyue WANG
;
Yongfeng YANG
;
Luxian LYU
;
Hongxing ZHANG
Author Information
1. 河南省精神病医院新乡医学院第二附属医院新乡市多模态脑影像重点实验室 453002
- Publication Type:Journal Article
- Keywords:
obsessive-compulsive disorder;
magnetic resonance imaging;
cerebellar;
orbitofrontal;
regional homogeneity;
functional connectivity
- From:
Chinese Journal of Psychiatry
2019;52(4):261-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of local cerebellar region in the pathogenesis of obsessive-compulsive disorder (OCD).Methods A total of 55 naive OCD patients and 50 normal controls (NC) matched with sex,age,ethnicity and education level were examined by using rs-fMRI and the image signals were analyzed and compared by Data Processing Assisstant for Resting-State fMRI V2.3 (DPARSF V2.3) and Rest Resting-state fMRI data analysis toolkit (Rest software).Two groups of regional homogeneity (ReHo) data were aralyzed by two sample t test,obtaine the abnormal brain regions of OCD group.The abnormal brain regions in OCD group,defined as regions of interest (ROI) by comparing with the NC group,were calculated in the whole brain functional connectivity (FC) analysis.Results (1) Compared with NC group,ReHo in OCD group significantly increased in left cerebellum region 8 (t=3.473 2) and right thalamus (t=4.321 7),while ReHo in OCD group significantly decreased in left medial orbital frontal gyrus (t=-4.582 6),the differences were all statistically significant (P＜0.05,Alphasim-corrected for multiple comparisons,cluster size＞40).(2) Abnormal functional connections were detected in the left medial orbital frontal gyrus,the left cerebellum region 8,and the right thalamus (P＜0.05,Alphasim-corrected for multiple comparisons,cluster size＞20).Conclusion OCD patients present a special circuit connecting the left medial orbitofrontal gyrus,the left cerebellum region 8,and the right thalamus,among which the left cerebellum region 8 may play an important role.
