Prognostic Value of COX Regression Model Based on ALBI Score,TBS Score and LDH Level in Patients with Hepatocellular Carcinoma af-ter Radical Liver Resection
10.11969/j.issn.1673-548X.2025.04.017
- VernacularTitle:基于ALBI评分、TBS评分及LDH水平构建的COX回归模型对HCC患者肝切除术后的预后价值
- Author:
Xuan ZHANG
1
;
Gennian WANG
;
Yongfang LI
Author Information
1. 730000 兰州大学第二临床医学院
- Publication Type:Journal Article
- Keywords:
Albumin-bilirubin score;
Tumor burden score;
Lactic dehydrogenase;
Radical hepatectomy;
Hepatocellular carcinoma
- From:
Journal of Medical Research
2025;54(4):89-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of albumin-bilirubin score(ALBI),tumor burden score(TBS)and lac-tate dehydrogenase(LDH)level in predicting the prognosis of HCC patients after radical hepatectomy.Methods The clinical data of pa-tients who underwent radical hepatectomy for primary liver cancer in the Department of General Surgery,The Second Hospital of Lanzhou University from January 2011 to January 2022 were retrospectively collected,including the patients'basic personal information,relevant laboratory tests,imaging data,pathological reports and follow-up data.This study involved 162 patients.The patients were divided into survival group and death group according to their survival status at the last follow-up,and the area under the receiver operating character-istic curve(AUC)was used to estimate the prediction accuracy of different models.Results During the study period,a total of 79 pa-tients(48.7％)died.The median survival time was 46.5months.AFP and LDH were identified as two independent risk factors for over-all survival after surgery by univariate and multivariate analysis(P＜0.05).The AUC of ALBI-TBS-LDH score for predicting death af-ter radical hepatectomy was higher than that of ALBI score and TBS score.According to the optimal Youden index,when the optimal diag-nostic cutoff value of ALBI-TBS-LDH score was-0.18,the sensitivity and specificity of predicting death were 63.4％and 71.8％,respectively.The 1-year,3-year and 5-year overall survival rates of patients with ALBI-TBS-LDH score＜-0.18 were 95.1％,80.5％and 39.0％,respectively;the 1-year,3-year and 5-year overall survival rates of patients with score≥-0.18 were 86.6％,59.7％and 22.4％,respectively,with statistically significant differences(P＜0.001).Conclusion The ALBI-TBS-LDH score can be used as a simple tool to evaluate the prognosis of HCC patients after liver resection,but its role still needs further research and verifica-tion.Patients with high ALBI-TBS-LDH scores have a higher incidence of postoperative death and a shorter survival time than those with low scores.
