Gender Difference in Associations between Serum Cholesterol Levels and Depression Symptoms in Healthy General Population.
- Author:
So Hee LEE
1
;
Mina PARK
;
Dae Hyun YOON
;
Young LEE
;
Sun Shin KIM
Author Information
1. Seoul National University Hospital, Healthcare System Gangnam Center, Seoul, Korea. kimss@sunh.org
- Publication Type:Original Article
- Keywords:
Cholesterol;
Beck depression inventory;
Gender
- MeSH:
Cholesterol*;
Cohort Studies;
Depression*;
Female;
Humans;
Male;
Retrospective Studies;
Triglycerides
- From:Korean Journal of Psychosomatic Medicine
2017;25(1):27-32
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to determine the association between serum lipid profiles and depression according to gender difference. METHODS: This retrospective cohort study included 27,452 subjects(15044 men and 12408 women) who underwent health examination. The duration was from January 2013 to December 2013. We estimate the correlation between serum lipid profile and Beck Depression Inventory(BDI) scores. We compare the effect size using beta coefficient. RESULTS: In men, serum Triglyceride level was correlated positively with BDI scores(r=0.020, p<0.01). Serum LDL-C and HDL-C were negatively correlated with BDI scores(r=-0.015, p<0.01 ; r=-0.016, p<0.05). In women, Triglyceride level was also correlated positively with BDI scores(r=0.020, p<0.01), Serum HDL-C were negatively correlated with BDI scores(r=-0.019, p<0.01). There was no statistical significance between Serum LDL-C and Beck Depression Inventory(BDI) score. CONCLUSIONS: Both men and women had more depressive symptoms when they had low serum HDL-C level or high serum Triglyceride level. The depression symptoms were more severe when serum LDL-C level was low only in men.
