Analysis of the Treatment of Multiple Infections in a Patient with Membranous Nephropathy Caused by Nocardia brasiliensis
10.3870/j.issn.1004-0781.2025.05.018
- VernacularTitle:1例巴西诺卡菌导致膜性肾病患者多发感染的治疗分析
- Author:
Ping YANG
1
;
Yanlin SHEN
1
;
Jia ZHOU
1
;
Jinlian ZHANG
1
Author Information
1. 上海交通大学医学院附属新华医院临床药学部,上海 200092
- Publication Type:Journal Article
- Keywords:
Nocardia infection;
Membranous nephropathy;
Sulfamethoxazole/trimethoprim;
Nervous injury
- From:
Herald of Medicine
2025;44(5):787-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and treatment strategies for Nocardia brasiliensis infection.Methods A clinical pharmacist participated in the clinical diagnosis and treatment plan for a case of a membranous nephropa-thy patient infected with Nocardia brasiliensis,resulting in multiple infections in the lungs,eyes,and nervous system.They were involved in assessing the patient's infection symptoms and severity,as well as reviewing the literature to participate in developing and optimizing the clinical drug therapy regimen.Results Following infection with Nocardia brasiliensis,the patient developed lung,eye,and nervous system infections.The patient showed significant improvement after targeted treatment by clinical doctors and clinical pharmacists.At the 3-month outpatient follow-up,the patient's lung,eye,and lower limb nervous system had re-turned to normal.Conclusions Nocardia brasiliensis can colonize in various environments,and immunocompromised individu-als are at risk of infection.Clinical diagnosis relies on metagenomic sequencing methods for identification.For mild to moderate in-fections,a combination of sulfamethoxazole/trimethoprim(TMP-SMX)can be used as monotherapy.Severe infections often re-quire a combination of two or three antibiotic drugs(such as TMP-SMX,imipenem cilastatin,amikacin)for intravenous treatment for 3-6 weeks,and followed by oral therapy.The entire course of treatment typically lasts 3-6 months.Patients with timely and ef-fective treatment usually have a better prognosis.
