Characteristics of resting-state functional connectivity in male adults with attention-deficit/ hyperactivity disorder
10.3760/cma.j.issn.1006-7884.2019.01.006
- VernacularTitle:男性成人注意缺陷多动障碍患者静息态脑功能连接特点
- Author:
Yawen TAN
1
;
Yanfei WANG
1
;
Meirong PAN
1
;
Fang HUANG
1
;
Mengjie ZHAO
1
;
Haimei LI
1
;
Lu LIU
1
;
Yufeng WANG
1
;
Qiujin QIAN
1
Author Information
1. 北京大学第六医院儿童精神病学研究室北京大学精神卫生研究所国家精神心理疾病临床医学研究中心(北京大学第六医院)国家卫生健康委员会精神卫生学重点实验室(北京大学),100191
- Publication Type:Journal Article
- Keywords:
Attention deficit disorder with hyperactivity;
Magnetic resonance imaging;
Adult;
Functional connectivity
- From:
Chinese Journal of Psychiatry
2019;52(1):70-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of resting-state functional connectivity in male adults with attention deficit hyperactivity disorder (ADHD) and the relationship with clinical symptoms.Method Forty-seven male adult ADHD patients diagnosed by DSM-Ⅳ-TR and 47 healthy controls matched with sex,age and IQ were enrolled by clinical interviews.All subjects underwent structural MRI scan and resting-state functional MRI scan.All subjects were rated the ADHD symptom severity with the ADHD symptom rating scale.A two independent-samples t-test was used to analyze the differences of the resting-state functional connectivity strength (FCS) between the male adult ADHD group and the healthy control group.Results Compared with healthy controls,adult ADHD patients had shown the reduced FCS in the right middle temporal gyrus(t=-3.42),inferior temporal gyrus (t=-3.32),right middle occipital gyrus (t=-3.11) and inferior occipital gyrus (t=-4.44,P＜0.05 after multiple correction).The FCS of right inferior occipital gyrus in ADHD group had a tendency to negatively correlated with the severity of symptoms (r=-0.403,P＜0.05).A trend of negative correlation between the FCS in the right inferior occipital gyrus in ADHD group and the attention deficit score was found (r=-0.507,P＜0.05).Conclusion Abnormalities in resting-state brain function connectivity are prominent in male adult ADHD patients.Occipitallobe dysfunction may be more related to the severity of the ADHD symptoms.Temporal lobe and occipital lobe seem to be crucial to the pathogenesis of adult male ADHD.
