The residual physical symptoms in Chinese patients with major depressive disorder after acute treatment phase: a cross-sectional survey among eleven mental health centers
10.3760/cma.j.issn.1006-7884.2019.01.007
- VernacularTitle:中国抑郁症患者急性期治疗后残留躯体症状的现况调查
- Author:
Xu ZHANG
1
;
Wei FENG
;
Gang WANG
;
Yongdong HU
;
Yajuan NIU
;
Jian HU
;
Xueyi WANG
;
Chengge GAO
;
Ning ZHANG
;
Yiru FANG
;
Jizhong HUANG
;
Tiebang LIU
;
Fujun JIA
;
Wenyuan WU
Author Information
1. 同济大学附属同济医院精神医学科,上海,200065
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Treatment outcome;
Quality of life;
Physical symptoms;
Social function
- From:
Chinese Journal of Psychiatry
2019;52(1):76-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence and characters of residual physical symptoms in Chinese depressive patients after acute treatment and the influence on the quality of life and social function.Methods In the multi-centers cross-sectional study,1 503 adult depressive outpatients,from 11 hospitals,who had been treated by antidepressants for 8-12 weeks with significant improvement of at least 50％ by Self-rating Visual Analog Scale were involved.The group with residual physical symptoms could be differentiated by Brief 16-Item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16) ＞5,while the QIDS-SR16 of remission group was ≤5.The QIDS-SR16,Patient Health Questionnaire-15 (PHQ-15),Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) and Sheehan Disability Scale (SDS) were used to assess the depressive symptoms,physical symptoms and social function.Results 49.8％ (748/1 503) patients had residual physical symptoms (PHQ-15＞4).The most common physical symptoms (PHQ-15≥1) were feeling tired or having low energy (56.3％,846/1 503),trouble sleeping (50.6％,760/1 503),headache(43.6％,655 / 1 503),constipation,loose stools or diarrhea(41.3％,620/1 503),feeling heart pound or race (37.6％,565/1 503),dizziness (34.0％,511/ 1 503),nausea,gas or indigestion (33.6％,505/1 503),etc.The 75.7％ (555/733) of the physical symptoms (PHQ-15＞4) in residual group was significantly higher than the 25.1％ (193/770;x2=385.38,P＜0.01) in remission group.The differences on social function (t=2.77-10.47) and life quality (t=3.04-11.41) between two groups were significant (P＜0.01).Generalized linear regression analysis showed that gender (female),present history of first episode were related to better social function,and the factors related to both social function and quality of life included residual depressive symptoms,residual physical symptoms of different severity,comorbid medical conditions,age,duration of antidepressant treatment for this episode.Conclusion The rate of residual physical symptoms is higher in patients with major depression who responded to acute phase treatment.The more severe the residual physical symptoms,the worse the quality of life and social function.It suggests that physical symptoms be focused in order to achieve clinical recovery.
