Analysis of influential factors on the prognosis of cerebral hemorrhage patients in vegetative state after comprehensive hyperbaric oxygen therapy
10.3760/cma.j.issn.1009-6906.2018.06.004
- VernacularTitle:高压氧综合康复治疗脑出血植物状态患者的预后影响因素分析
- Author:
Yi ZHANG
1
;
Linlin MA
1
;
Zhuo LI
1
;
Yu GAO
1
;
Liming ZHAO
1
;
Chunjin GAO
1
;
Jing YANG
1
Author Information
1. 首都医科大学附属北京朝阳医院高压氧科, 北京,100020
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Vegetative state;
Hyperbaric oxygen;
Influential factor
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2018;25(6):354-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effects of comprehensive hyperbaric oxygen therapy (HBO) on cerebral hemorrhage patients in vegetative state (VS) and influential factors on the prognosis of cerebral hemorrhage.Methods Seventy-five cerebral hemorrhage patients who were admitted into the Department of Hyperbaric Oxygen,Beijing Chaoyang Hospital and conformed to the criteria of vegetative state were enrolled for the study.All the patients received 3 to 6 courses of comprehensive HBO therapy and completed 6-month medical follow-ups.Then,improvement of cognition was evaluated before comprehensive HBO therapy,at the 3-month and 6-month medical follow-ups respectively by using the Coma Recovery Scale-Revised (CRS-R).Results At the 3-month and 6-month medical follow-ups,the CRS-R scores were considerably improved as compared with those before treatment,and statistical significance could be seen when comparisons were made between the groups (P ＜ 0.01).At the 6-month follow-up,22 patients regained consciousness,accounting for (29.3％),and 53 patients still had conscious disorder,accounting for 70.7％.With regard to age,gender,causes of cerebral hemorrhage,sites of cerebral hemorrhage,ventricular hemorrhage and courses of HBO therapy,no statistical significance could be noticed in the patients who recovered consciousness at the 6-month medical follow-up,when compared with those who still had conscious disorder(P ＞0.05).As compared with those who had conscious disorder,the CRS-R scores of the patients in the conscious recovery group before treatment were higher.HBO At the 6-month follow-up,the conscious recovery rate of the patients with the amount of hemorrhage equal or lower than 45 ml (40.5％) was obviously higher than that of the patients with the amount of hemorrhage higher than 45 ml (18.4％),and statistical significance could be noted when comparisons were made between them (P ＜ 0.05 or P ＜ 0.01).Logistic regression analysis indicated that the amount of hemorrhage (＞ 45 ml/≤45 ml,OR =8.944,P =0.049),the time of comprehensive HBO therapy (OR =1.182,P =0.006),the CRS-R scores before treatment (OR =0.040,P =0.000) were related with the prognosis of the patients.Conclusion In the treatment of cerebral hemorrhage patients in vegetative state,the amount of hemorrhage,the time of comprehensive HBO therapy and the CRS-R scores before treatment were all influential factors that affected the prognosis of the patients.For this reason,comprehensive HBO therapy should be administered as early as possible.
