Effects of warm water bath rewarming on blood biochemistry and coagulation in rats with hypothermia induced by prolonged seawater immersion
10.3760/cma.j.issn.1009-6906.2018.05.001
- VernacularTitle:温水浴复温对长时程海水浸泡体温过低大鼠血液生化及凝血的影响
- Author:
Yuanyuan QIAO
1
;
Chenghe SHI
;
Jianbo HUAN
;
Lina CHEN
;
Licheng SONG
;
Hao CHENG
;
Dajin ZHANG
;
Zhihai HAN
Author Information
1. 海军总医院海战伤救治研究中心, 北京,100048
- Publication Type:Journal Article
- Keywords:
Seawater immersion;
Hypothermia;
SD rat;
Warm water bath rewarming;
Passive rewarming;
Blood biochemistry;
Coagulation
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2018;25(5):273-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes in blood biochemistry and coagulation function before and after warm water bath rewarming in SD rats with hypothermia induced by prolonged seawater immersion . Methods One hundred male Sprague-Dawley rats were randomly divided into the normal control group ( the NC group, without any treatment ) and the hypothermia group ( the HT group, exposed to seawater immersion at 20 ℃for 24 hours).The passive rewarming sub-groups (the pR group 1, 2, 3 and 4, n=10) (exposed to seawater immersion at 20 ℃for 24 hours +passive rewarming ) were respectively executed after rewarming at hour 0, hour 3, hour 6, and hour 12).The warm-water bath rewarming sub-groups (the wR group 1, 2, 3 and 4, n=10 ) ( exposed to seawater immersion at 20 ℃ for 24 hours +warm-water bath rewarming ) were respectively executed after rewarming at hour 0, hour 3, hour 6, and hour 12).Blood samples were taken from abdominal aorta for biochemical and coagulation detection .Results Zero to 3 hours after warm water bath rewarming , important parameters of hepatic and renal functions , as well as myocardial enzymes in the SD rats with hypothermia induced by prolonged seawater immersion remained at high levels or even increased to some extent.Only after 6 hours after rewarming , the above-mentioned parameters dropped considerably .However, coagulation indicators began to decline immediately after rewarming , and as compared with the passive rewarming , warm water bath rewarming could produce obviously better effects on the alleviation of abnormal hepatic and renal functions, as well as myocardial enzyme parameters (P<0.05).Conclusion Warm water bath rewarming could produce better effects on the recovery of serum biochemical parameters in rats with hypothermia induced by prolonged seawater immersion when compared with those of passive rewarming .
