Research progress of blood-nerve barrier in diabetic peripheral neuropathy

VernacularTitle:血-神经屏障在糖尿病周围神经病变中机制的研究进展
Author: Rui DING ¹ ; Xiaoyan ZHAO ; Haoyue FENG ; Xitao MA ; Maoyi YANG ; Rensong YUE
Author Information

1. 710000 西安,陕西省中医医院内分泌一科
Publication Type:Journal Article
Keywords: Diabetic peripheral neuropathy; Peripheral nerve; Blood nerve barrier; Microvascular
From: Chinese Journal of Diabetes 2025;33(5):378-382
CountryChina
Language:Chinese
Abstract: [Summary]Diabetic peripheral neuropathy(DPN)is one of the most common complications of diabetes.The blood nerve barrier(BNB)is a barrier structure located in peripheral nerve tissue,protecting nerve tissue from toxic substances in the blood and maintaining material exchange and information transmission between nerves and blood.Studies have shown that changes in BNB may be the initial event leading to the occurrence of DPN.After BNB is destroyed,blood-borne pathogens can directly damage peripheral nerves and cause DPN.This article will review the physiological and pathological characteristics of BNB,the relationship between BNB and DPN,and the research progress in targeting BNB for the treatment of DPN.