Association between skeletal muscle fat content and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.05.002
- VernacularTitle:2型糖尿病患者骨骼肌脂肪含量与糖尿病周围神经病变相关性的研究
- Author:
Jinghe HUANG
1
;
Mingzhu ZOU
;
Jingtao QIAO
;
Ran WEI
;
Zhenxing WANG
;
Yan SONG
;
Lixin GUO
Author Information
1. 100730 北京医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetic peripheral neuropathy;
Diabetes mellitus,type 2;
Ectopic fat deposition;
Skeletal muscle fat;
Quantitative CT
- From:
Chinese Journal of Diabetes
2025;33(5):328-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between skeletal muscle fat content and diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes mellitus(T2DM).Methods 290 patients with T2DM admitted to our hospital were enrolled in this study from January 2023 to February 2024 and divided into two groups according to whether they were complicated with DPN:simple T2DM group(T2DM,n=98)and T2DM with DPN group(DPN,n=192).The general data,biochemical indexes and fat distribution indexes measured based on quantitative CT were compared between the two groups.Spearman correlation was used to analyze the relationship between fat distribution indexes and DPN,logistic regression analysis of influencing factors of T2DM complicated with DPN.Results Age,DM duration,WHR,FIns,insulin resistance index(HOMA-IR)and FF were higher in DPN group than in T2DM group(P<0.05).Ca,subcutaneous abdominal fat area(SFA)and liver fat content were lower in DPN group than in T2DM group(P<0.05).Spearman correlation analysis showed that DPN was negatively correlated with SFA and liver fat content(r=-0.127,-0.123,P<0.05),and positively correlated with FF(r=0.117,P<0.05).Logistic regression analysis showed that without adjusting for confounding factors and adjusting for DM duration,WHR,HOMA-IR,Ca,SFA and liver fat content,FF was an influential factor for DPN in T2DM patients.Conclusions Skeletal muscle FF was associated with DPN in patients with T2DM.
