Research progress of mitochondrial quality control in diabetic retinopathy
10.3969/j.issn.1006-6187.2025.05.015
- VernacularTitle:糖尿病视网膜病变线粒体质量控制的研究进展
- Author:
Junfang FAN
1
;
Jiangning YIN
1
;
Shihan LOU
1
Author Information
1. 210000 南京市江宁医院急诊科
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Mitochondrial dysfunction;
Mitochondrial quality control
- From:
Chinese Journal of Diabetes
2025;33(5):392-395
- CountryChina
- Language:Chinese
-
Abstract:
[Summary]Diabetic retinopathy is the most common diabetic microvascular complication and the leading cause of vision loss in adults.Mitochondrial quality control regulates the quality and quantity of mitochondria through a series of processes to maintain mitochondrial function and homeostasis.These processes include mitochondrial biogenesis,mitochondrial dynamics and mitochondrial autophagy,abnormalities of which can lead to mitochondrial dysfunction.Current studies have shown that mitochondrial dysfunction is associated with a variety of diseases,including neurodegenerative diseases,tumors,cardiovascular diseases and diabetes.At present,there are few studies on mitochondrial dysfunction and DR.This paper reviews the literature on mitochondrial quality control and DR,discusses the possible role of mitochondrial dysfunction in the occurrence and development of DR in order to seek possible molecular therapeutic targets.
