The diversity and the abundance of gut microbiome in patients with bipolar disorder
10.3760/cma.j.issn.1006-7884.2018.02.005
- VernacularTitle:双相障碍不同临床相肠道菌群多样性及相对丰度的对照研究
- Author:
Liyang GUO
1
;
Cui JI
1
;
Qingyan MA
1
;
Yajuan FAN
1
;
Junqin FENG
1
;
Ce CHEN
1
;
Yunchun CHEN
1
;
Chengge GAO
1
;
Feng ZHU
1
;
Xiancang MA
1
;
Wei WANG
1
Author Information
1. 710061,西安交通大学第一附属医院精神心理科
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Mania;
Depressive;
Gut microbiota
- From:
Chinese Journal of Psychiatry
2018;51(2):98-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the changes in composition of gut microbiome in patients with different clinical phases of bipolar disorder(BD). Method A total of 28 healthy controls and 31 BD patients including 19 patients with manic episode(BDM group)and 12 patients with depressive episode (BDD group), were enrolled in this study. Baseline characteristics and diet were collected from all participants. Stool samples were collected to extract genomic DNA for PCR and bioinformatics analysis. 16S rRNA sequencing technology was used to obtain gut microbiome diversity among groups subsequently. QIIME was used to calculate observed species index,shannon index,simpson index,psylogenetic diversity index for each group.Linear discriminant analysis(LDA)using LEfSe software was screening for differences species among four groups. Results There was no significant difference between baseline characteristics and diet among four groups. Comparison of gut microbiome alpha diversity among groups, the gut microbiome diversity of BD group were all significantly higher than that in healthy control group,including observed species index(312.0±71.0 vs.229.3±38.6,t=5.475,P<0.01),shannon index(4.9±0.8 vs.3.7±0.9,t=5.747,P<0.01),simpson index(0.9±0.1 vs.0.8±0.1,t=4.446,P<0.01),psylogenetic diversity index(23.7±4.6 vs. 20.2±5.2,t=2.715,P<0.01),especially in BDM group.In composition of gut microbiome(LDA>4,P<0.05)the relative abundance of proteobacteria, ruminococcus, veillonella and lanchnospira in BD group were significantly higher than that in controls, but the relative abundance of bacteroides was significantly lower than that in controls. The relative abundance of enterobacteriaceae, ruminococcus, megamonas and bifidobacterium adolescentis in BDM groups were significantly higher than that in controls,while the relative abundance of bacteroides was significantly lower.The relative abundance of selenomonadales,lachnospira, eubacrerium and plebeius in BDD group were significantly higher than that in controls, while the relative abundance of plebeius was significantly lower. The relative abundance of eschericha coli and bifidobacterium adolescentis of BDM group were significantly higher than that in BDD group, while the relative abundance of stercoris in BDD group was significantly higher than that in BDM group. Conclusion The gut microbiome diversity of patients with BD may be increased and the abundance of several bacterial species changed.
