Study of risk factors and serum bile acid profile characteristics in Crohn's disease patients complicated by gallstones
10.3760/cma.j.cn101480-20250109-00009
- VernacularTitle:克罗恩病并发胆囊结石的危险因素及胆汁酸谱特征研究
- Author:
Yan GONG
1
;
Yishu HE
;
Mengting WAN
;
Hong CHEN
Author Information
1. 东南大学医学院，南京 210009
- Publication Type:Journal Article
- Keywords:
Crohn's disease;
Gallstones;
Extraintestinal manifestations;
Ileocolonic type;
Bile acid profile;
Incidience;
Risk factor
- From:
Chinese Journal of Inflammatory Bowel Diseases
2025;09(6):469-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence, risk factors, and bile acid profile characteristics of Crohn's disease (CD) patients complicated by gallstones.Methods:A retrospective observational study was conducted. Clinical data of CD patients admitted to Zhongda Hospital of Southeast University from January 2020 to December 2023 were collected. Patients were divided into the gallstone group and the non-gallstone group according to the presence of gallstones. Univariate analysis and Logistic multivariate analysis were perfomed to identify the risk factors of CD patients complicated by gallstones. Sixty-eight CD patients in remission were selected, and serum levels of 15 bile acids were compared between patients with and without gallstones.Results:A total of 296 CD patients were enrolled, including 211 males and 85 females, with a mean age of 37.8 ± 14.8 years, disease duration of 2.0 (1.0, 6.0) years, Crohn's disease activity index of 265.3 ± 121.2, and body mass index of 22.4±2.2 kg/m 2. Among them, 44 patients (14.9%) had gallstones and were assigned to the gallstone group, while the remaining 252 patients (85.1%) were assigned to the non-gallstone group. Univariate analysis and multivariate Logistic regression analysis showed that location was an independent risk factor for CD patients complicated by gallstones. Patients with ileocolonic CD have a 3.92-fold higher risk of developing gallstones than those with colonic CD ( OR=3.92, 95% CI: 1.13-13.61, P = 0.031). Analysis of bile acid profiles in 68 CD patients in remission revealed that, compared to those without gallstones ( n = 50), patients with gallstones ( n = 18) had lower levels of ursodeoxycholic acid and an higher ratio of secondary conjugated bile acid/secondary free bile acid, the differences were significant (both P < 0.05) . Conclusions:CD patients have a high incidence of gallstones, which may be associated with abnormal bile acid metabolism. The ileocolonic CD patients are more prone to developing gallstones.
