Abnormal functional connectivity of dorsolateral prefrontal cortex in patients with bipolar Ⅱdepression under the resting state
10.3760/cma.j.issn.1006-7884.2018.02.004
- VernacularTitle:双相障碍Ⅱ型抑郁患者静息态背外侧前额叶皮质功能连接的异常
- Author:
Feng YAN
1
;
Li WANG
;
Ke LI
;
Yawei ZENG
;
Yunai SU
;
Zhen JIN
;
Tianmei SI
Author Information
1. 100096,北京回龙观医院
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Magnetic resonance imaging;
Resting state;
Dorsolateral prefrontal cortex
- From:
Chinese Journal of Psychiatry
2018;51(2):93-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of functional connectivity patterns of dorsolateral prefrontal cortex(DLPFC)related to emotion management in patients with bipolar Ⅱdepression under the resting state. Methods The general demographic and clinical data of 30 patients with bipolar Ⅱdepression and gender-and age-matched healthy controls were collected.All subjects completed the resting-state functional magnetic resonance scans. After the imaging preprocessing, seed- based functional connectivity analysis was performed on the bilateral DLPFC using REST software.The single sample t test was used to analyze the connection distribution pattern of each DLPFC region of interest in the group.The independent sample t test was used to compare the differences between two groups of DLPFC functional connections with age and sex covariate.Subsequently,Pearson correlation analysis was performed between the mean connectivity values of regions showing significant group differences and depressive severity (HAMD17scores). Results Compared with healthy controls, patients with bipolar Ⅱ depression showed abnormally increased functional connectivity between the left DLPFC seed and the right superior medial frontal gyrus, left superior, middle, inferior temporal gyri, right superior temporal gyrus and right parahippocampal gyrus(t=4.809,4.689,4.912;all P<0.05), while the functional connectivity was abnormally decreased between the left DLPFC and the left inferior parietal lobule, left superior medial frontal gyrus(t=-4.065,4.625; both P<0.05). The right DLPFC showed abnormally reduced functional connectivity with the right middle frontal gyrus(MNI:x=42,y=36,z=30;t=-5.093,P<0.05)and the right inferior frontal gyrus(MNI:x=6,y=21,z=45;t=-4.553,P<0.05). No significant correlations were found between the mean connectivity values of the regions showing significant group differences and depressive severity (HAMD17scores). Conclusion The results suggest that patients with bipolar Ⅱ depression have altered resting state functional connectivity in the bilateral DLPFC, which may be a biological basis for abnormal emotion management of bipolar Ⅱ depression patient. Its specificity still needs to be compared with other related diseases.
