Effects of hyperbaric oxygen on the proliferation of fibrous tissue in the rabbit model of nasal cavity surgery
10.3760/cma.j.issn.1009-6906.2018.02.007
- VernacularTitle:高压氧对鼻腔手术模型兔鼻黏膜纤维组织增生的影响
- Author:
Jing LONG
1
;
Zhu SHI
;
Xinghua DENG
Author Information
1. 四川省凉山州第一人民医院耳鼻咽喉科,四川省西昌,615000
- Publication Type:Journal Article
- Keywords:
Otorhinolaryngologic surgery;
Hyperbaric oxygen;
Nasal mucosa;
Tissue adhesion;
Cicatrix;
Rabbits
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2018;25(2):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of hyperbaric oxygen (HBO) on scar adhesion and fibrous connective tissue hyperplasia after nasal cavity surgery in rabbits.Methods Chosen for the study were 21 rabbits,of which 5 rabbits were assigned as the control group,and the bilateral nasal cavity model was developed by using the remaining 16 rabbits,and the animals were randomly divided into the HBO group and the non-HBO group,each consisting of 8 animals.The HBO group received HBO therapy on the 5th day after surgery,at a pressure of 0.2 MPa (2.0 ATA),once a day,for a total of 20 sessions,while the control group and the non-HBO group remained intact at atmospheric pressure.In the 6th week,the animals were sacrificed and bilateral inferior turbinate mucosa was taken for the observation of general morphlogical and pathological changes.Results There was scar formation at one side for the animals of the HBO group,but without adhesion,however,there were 7 cases of scar adhesion in the non-HBO group.As compared with that of the non-HBO group,scar adhesion of the HBO group reduced significantly,and statistical significance was noted,when comparisons were made between them (P ＜ 0.01).There were 5 cases of mild fibrous connective tissue hyperplasia and 1 case of moderate hyperplasia,in the HBO group,while there were 7 cases of mild hyperplasia and 4 cases of hyperplasia in the non-HBO group.Hyperplasia in the HBO group was obviously less,when compared with that in the non-HBO group,and statistical significance was be found,when comparisons were made between them (P ＜ 0.05).Conclusions HBO therapy could effectively reduce the proliferation of fibrous connective tissue and reduce the formation of scar adhesion.
