Directing the surgical treatment of Crohn's disease within treat-to-target and disease clearance concept

VernacularTitle:以达标治疗和疾病清除理念指导克罗恩病的外科治疗
Author: Zhenya SUN ¹ ; Zhenxing ZHU ; Weiwei WEN ; Yuxia GONG ; Bolin YANG ; Weiming ZHU
Author Information

1. 南京中医药大学附属医院肛肠科　210029
Publication Type:Journal Article
Keywords: Crohn's disease; Surgical treatment; Disease clearance; Treat-to-target
From: Chinese Journal of Inflammatory Bowel Diseases 2025;09(4):274-278
CountryChina
Language:Chinese
Abstract: Crohn's disease (CD) is a chronic progressive inflammatory bowel disease. With the introduction of the "treat-to-target (T2T) " concept, the treatment goals for CD have become clearer and more specific. Traditional surgical treatment for CD typically follows a "complication-driven" approach, in which surgery is usually performed only after severe complications, such as bowel obstruction, fistulas, perforation, or cancer have occurred. The emergence of the treat-to-target strategy and the concept of disease clearance has transformed the surgical treatment of CD from a "passive rescue" model to an "active intervention" approach. Treatment goals have shifted from merely addressing complications and improving symptoms to achieving both short and long-term therapeutic objectives within the framework of treat-to-target. Achieving these goals helps to prevent CD-related complications, delay disease progression, reduce the risk of recurrence and malignancy, and improve the quality of life.