Effects of hyperbaric oxygen on cellular immune function in the patients with stable chronic obstructive pulmonary disease
10.3760/cma.j.issn.1009-6906.2018.02.009
- VernacularTitle:高压氧对稳定期慢性阻塞性肺疾病患者细胞免疫功能的影响
- Author:
Yongxin MA
1
;
Zhaofen LIU
;
Yanli YU
;
Zhenying ZHANG
;
Xiaoxia LIU
Author Information
1. 潍坊市人民医院康复医学科高压氧治疗中心, 山东省潍坊,261041
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Chronic obstructive pulmonary disease;
Cellular immune function
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2018;25(2):99-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the level of cellular immune function in the patients with stable chronic obstructive pulmonary disease(COPD),and also to investigate the effects of hyperbaric oxygen (HBO) on the cellular immune function in the patients with stable COPD.Methods One hundred and sixty-seven cases of stable COPD were divided into 2 groups,the drug inhalation group (n =81),which inhaled tiotropium bromide and the HBO group (n =86),which received HBO therapy in addition to drug inhalation.Another 33 normal health subjects were recruited as the normal control group.Immune function indexes of the 3 groups were detected and analyzed before and after therapy.Results The IL-2R level and lymphatic metastasis rate of the HBO group and the drug inhalation group were respectively [(218.95 ± 106.60) μg/ml,(235.60 ± 67.85)μg/ml] and [(42.15 ± 5.75)％,(42.52 ± 5.75)％],CD3 and CD4 levels were respectively [(47.05±7.76)％,(47.20 ±7.63)％] and [(36.20 ±6.05)％,(34.67 ±4.51)％].Statistical significance could be found when they were compared with those of the normal control group [(389.13 ± 191.42)μg/ml,(77.60±5.29)％,(65.70±6.30)％,(44.50±4.70)％](P＜0.01).For the HBO group,significant improvement could be seen in cellular immune indexes,pulmonary ventilation function and hypoxemia after therapy,and there was statistical significance when compared with those data before therapy (P ＜ 0.05).There was also significant improvement in cellular immune indexes for the patients of the HBO group,as compared with those of the drug therapy group,and statistical significance could be noted when comparisons were made between the 2 groups (P ＜ 0.01).Conclusions The cellular immune levels of the patients with stable COPD were decreased to various degrees.HBO therapy could significantly improvethecellular immune function of the patients with stable COPD,rectify hypoxia and carbon dioxide retention and improve pulmonary function.
