Characters of cortical thickness and mean curvature of first episode schizophrenia
10.3760/cma.j.issn.1006-7884.2018.01.007
- VernacularTitle:首次发病精神分裂症患者大脑皮质厚度和平均曲率的特征分析
- Author:
Hui LI
1
;
Fengmei FAN
;
Hong XIANG
;
Hongzhen FAN
;
Shiyou TANG
;
Yun WEN
;
Zhiren WANG
;
Yunlong TAN
;
Shuping TAN
Author Information
1. 100096,北京回龙观医院北京大学回龙观临床医学院
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Cortical thickness;
Mean curvature
- From:
Chinese Journal of Psychiatry
2018;51(1):28-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characters of cortical thickness and mean curvature for the patients with the first episode schizophrenia and explore the relationship with clinical symptoms.Method Eighty-six patients with first episode schizophrenia and 49 healthy controls were recruited.The structure data of T1 image was processed using FreeSurfer automatic package and obtained cortical thickness and mean curvature.These brain morphological indicators were compared between patients and healthy controls.For the patient group,Pearson correlation between cortical thickness,mean curvature and clinical symptoms was calculated.Results Compared with controls,the cortical thickness of bilateral central sulcus (left:(1.897±0.102) mm vs.(1.814±0.108) mm;right:(1.871 ±0.119) mm vs.(1.784±0.108) mm) was thicker in patient group (F=24.24,18.59;both P＜0.00 067);while the bilateral superior segment of the circular sulcus of the insula (left:(2.495±0.122) mm vs.(2.591±0.138) mm;right:(2.602±0.133) mm vs.(2.710±0.131) mm) and left anterior transverse collateral sulcus ((2.599±0.250) mm vs.(2.782±0.238) mm) were thinner in patient group (F=16.75,22.61,18.86,both P＜0.00 067).Patients with schizophrenia showed significant (F=14.52,13.08,both P＜0.000 67) higher mean curvature than healthy control only in post central gyrus ((0.166±0.026) mm-1 vs.(0.150±0.011) mm-1) and inferior temporal gyrus ((0.186±0.016) mm-1 vs.(0.177±0.011) mm-1) of the left brain;while in the right brain,patient group showed significant (F=14.20,14.42,12.75,15.02,14.80,12.16,13.74,16.70,12.77,all P＜0.000 67)higher mean curvature than healthy control in the middle frontal gyrus,frontal polar transverse gyrus and sulcus,lateral orbital sulcus,anterior cingulate cortex,the middle of the occipital-temporal sulcus and lingual sulcus,superior segment of the circular sulcus of the insula,cuneus,precuneus and superior occipital gyrus.The cortical thickness of left anterior transverse collateral sulcus showed positive correlation with PANSS total score (r=0.322,P＜0.01).The mean curvature of right anterior cingulate cortex showed negative correlation with PANSS negative scale (r=-0.262,P＜0.05).The mean curvature of right superior segment of the circular sulcus of the insula had a positive correlation with PANSS positive scale (r=0.240,P＜0.05).Tbe mean curvature of right collateral sulcus and lingual sulcus showed negative correlation with PANSS total score (r=-0.260,P＜0.05).Conclusions Cortical thickness and mean curvature displayed abnormally in multi regions of the first episode schizophrenia compared with healthy control.Besides that,some of the abnormal brain morphological indicators correlated with the clinical symptoms severity.
