Application progress of single-cell RNA sequencing in the pathogenesis, diagnosis and treatment of inflammatory bowel disease
10.3760/cma.j.cn101480-20240524-00061
- VernacularTitle:单细胞RNA测序在炎症性肠病发病机制及诊治中的应用进展
- Author:
Jiang YU
1
;
Xiaojing ZHAO
1
;
Hongjie ZHANG
1
Author Information
1. 南京医科大学第一附属医院消化内科，南京 210029
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Single-cell RNA sequencing;
Pathogenesis;
Diagnosis;
Treatment
- From:
Chinese Journal of Inflammatory Bowel Diseases
2025;09(3):233-237
- CountryChina
- Language:Chinese
-
Abstract:
The application of single-cell RNA sequencing (scRNA-seq) technology in the pathogenesis, diagnosis and treatment of inflammatory bowel disease (IBD) has received widespread attention. scRNA-seq technology can probe into the relationships between biomolecules at the single-cell level, allowing the discovery of previously unknown cell types, which can help to deepen the understanding of complex diseases such as IBD. This article reviews the research progress of scRNA-seq in IBD, including the exploration of the pathogenesis of IBD, the revelation of the similarities and differences between different types of IBD, the prediction of efficacy and prognosis of IBD drugs, hoping to provide useful help to scholars who study IBD by using scRNA-seq technology.
