Progress on functional magnetic resonance imaging study of brain functional changes in Crohn's disease

VernacularTitle:克罗恩病脑功能改变的功能磁共振成像研究进展
Author: Yuhan DONG ¹ ; Zongjun LYU ; Tingting FANG ; Haiyan LIU ; Jianguo ZHU
Author Information

1. 南京医科大学第二附属医院医学影像科，南京　210011
Publication Type:Journal Article
Keywords: Crohn's disease; Functional magnetic resonance imaging; Brain function; Brain-gut axis; Anxiety; Depression
From: Chinese Journal of Inflammatory Bowel Diseases 2025;09(2):154-157
CountryChina
Language:Chinese
Abstract: Crohn's disease (CD) is a refractory and recurrent chronic inflammatory bowel disease with an unclear etiology. In addition to intestinal symptoms, the disease is often accompanied by various extraintestinal manifestations. Studies have found that abnormalities in central nervous system activity in CD patients are closely related to the brain-gut axis, which may be one of the reasons for the high incidence of adverse emotions such as anxiety and depression. Functional magnetic resonance imaging (fMRI) has been widely used in the field of neurogastroenterology due to its non-invasiveness, high spatial resolution, and whole-brain coverage. This article reviews the application and progress of fMRI in CD brain functional study, aiming to comprehensively analyze and integrate the impact of the disease on brain function and provide a reference for clinical diagnosis, treatment, and future research.