Advances in the pathogenesis of chronic enteropathy associated with SLCO2A1 gene
10.3760/cma.j.cn101480-20240319-00039
- VernacularTitle:SLCO2A1基因相关慢性肠病的发病机制研究进展
- Author:
Jingyi HUANG
1
;
Changzheng LIU
;
Yue LI
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院消化内科，北京 100730
- Publication Type:Journal Article
- Keywords:
Chronic enteropathy associated with SLCO2A1 gene;
Gene, SLCO2A1;
Organic anion transporting polypeptide 2A1;
Prostaglandin E2;
Primary hy
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(6):458-461
- CountryChina
- Language:Chinese
-
Abstract:
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare disease characterized by multiple non-specific superficial ulcers in the small intestine, for which there is a lack of effective medical treatment. Loss-of-function mutations in the SLCO2A1 gene contribute to the onset of CEAS. However, the downstream target cell and molecular mechanisms of the gene mutation still require further investigation. In this article, we comprehensively review recent findings regarding the pathogenesis of CEAS, encompassing five aspects: PGE2 metabolic disorder, immunology, endothelial dysfunction, Maxi-Cl channel, and epigenetics, while also presenting future prospects and outlook.
