Intratumoral tertiary lymphoid structure for predicting prognosis of soft tissue sarcoma after cryoablation combined with immunotherapy
10.13929/j.issn.1672-8475.2025.05.003
- VernacularTitle:瘤内三级淋巴结构用于预测软组织肉瘤经冷冻消融联合免疫治疗后预后
- Author:
Juxing CAI
1
;
Guangzhao LI
;
Baorang ZHU
;
Jing LI
;
Wuwei YANG
Author Information
1. 中国人民解放军医学院,北京 100853;中国人民解放军总医院第五医学中心肿瘤医学部,北京 100071
- Publication Type:Journal Article
- Keywords:
sarcoma;
tertiary lymphoid structures;
immunotherapy;
cryosurgery;
progression free survival
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(5):315-318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of intratumoral tertiary lymphoid structure(TLS)for predicting prognosis of soft tissue sarcomas(STS)after cryoablation combined with immunotherapy.Methods Forty-three STS patients who underwent cryoablation were retrospectively enrolled,including 38 cases underwent cryoablation combined with but 5 cases without immunotherapy,among them 6 cases with but 37 cases without intratumoral TLS.The progression free survival(PFS)were compared between those with and without immunotherapy,as well as those with and without intratumoral TLS.The value of intratumoral TLS for predicting prognosis of STS after cryoablation combined with immunotherapy was analyzed with Cox regression and receiver operating characteristic curves.Results No significant difference of PFS was found between STS patients undwerwent cryoablation combined with and without immunotherapy(P＜0.05).Among 38 cases underwent cryoablation combined with immunotherapy,6 cases were found with but 32 cases without intratumoral TLS,and the median PFS of the former was longer than that of the latter(6 months vs.3 months,P＜0.05).Univariate and multivariate Cox regression analysis revealed that intratumoral TLS and interleukin 2 receptor(IL-R2)were both independent influencing factors of PFS of STS patients after cryoablation combined with immunotherapy(both P＜0.05).The area under the curve(AUC)of intratumoral TLS for predicting PFS of STS patients at 3,6 and 9 months was 0.550,0.577 and 0.699,of IL-R2 was 0.658,0.742 and 0.583,respectively,while of combination of the above two was 0.762,0.787 and 0.881,respectively,all higher than of each intratumoral TLS and IL-R2 alone(all P＜0.05).Conclusion Intratumoral TLS could be used to predict prognosis of STS after cryoablation combined with immunotherapy.Combining with IL-R2 might further improve its predictive efficacy.
