Impact of psychiatric and psychological disorders on the incidence risk of non-alcoholic fatty liver disease:A two-sample Mendelian randomization analysis
10.13602/j.cnki.jcls.2025.10.13
- VernacularTitle:精神心理障碍对非酒精性脂肪性肝病发病风险的影响:双样本孟德尔随机化研究
- Author:
Jiaming ZHANG
1
;
Shangdong YANG
1
;
Yang XIAO
1
;
Wen XI
1
;
Junhui LIU
1
;
Wei CHEN
1
Author Information
1. 西安交通大学第一附属医院检验科,西安 710061
- Publication Type:Journal Article
- Keywords:
depression;
bipolar disorder;
schizophrenia;
non-alcoholic fatty liver disease;
Mendelian randomization
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(10):787-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between psychiatric and psychological disorders(depression,bipolar dis-order,and schizophrenia)and non-alcoholic fatty liver disease(NAFLD).Methods The two-sample Mendelian randomization(MR)method was adopted,with depression,bipolar disorder,and schizophrenia as exposure variables and NAFLD as the outcome variable.The single nucleotide polymorphisms(SNPs)independently associated with exposure variables were obtained from the summary data of the genome-wide association study(GWAS)as instrumental variables for MR analysis.The analysis results of the inverse-variance weighted(IVW)were used as the primary outcome indicators,while those of the MR Egger regression method,weighted median,and weighted mode as supplementary results.The Cochran's Q test,MR-Egger intercept,and"leave-one-out"method were used for sensi-tivity analysis.Results The results of IVW analysis showed that depression was positively correlated with the incidence risk of NAFLD(OR=1.21,95％CI:1.01-1.44,P＜0.05),while bipolar disorder was negatively correlated with the incidence risk of NAFLD(OR=0.91,95％CI:0.84-1.00,P＜0.05).No causal relationship was found between schizophrenia and NAFLD.The heterogeneity and sen-sitivity analysis supported the robustness of the results of the study.Conclusion Depression and bipolar disorder are causally associat-ed with the incidence of NAFLD.Depression is associated with an increased risk of NAFLD,while bipolar disorder is associated with a reduced risk of NAFLD.
