Correlation analysis between inflammatory markers in complete blood counts and influenza A virus infection
10.13602/j.cnki.jcls.2025.10.12
- VernacularTitle:全血细胞计数中炎症指标与甲型流感病毒感染的相关性分析
- Author:
Zexin DONG
1
;
Ling JIN
1
;
Bangshun HE
1
;
Weiwei CUI
1
Author Information
1. 南京医科大学附属南京医院&南京市第一医院医学检验科,南京 210006
- Publication Type:Journal Article
- Keywords:
complete blood count;
inflammatory marker;
influenza A virus;
lymphocyte count;
monocyte/lymphocyte ratio
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(10):780-786
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze the correlation between inflammatory markers in complete blood counts(CBC)and influenza A virus infection in patients visited the outpatient department of Nanjing First Hospital.Methods The suspected influenza A virus infection patients visited the outpatient department of Nanjing First Hospital from February to March 2023 were collected and di-vided into the positive and negative groups based on the detection results of influenza A virus antigen.The differences in inflammatory markers in CBC between the two groups were compared.The Logistic regression analysis was used to evaluate the correlation between inflammatory markers and influenza A virus infection.Meanwhile,the restricted cubic spline(RCS)and age subgroup(≤6 years,7-12 years,13-17 years,and ≥18 years)analysis were also performed.Results A total of 1 487 outpatients were included,of which 404(27.2％)were positive for influenza A virus antigen.The Logistic regression analysis showed that white blood cell count(WBC),lymphocyte percentage(LY％),and lymphocyte count(LYM)were significantly negatively correlated with influenza A virus infection(P＜0.01),while the neutrophil percentage(NE％),monocyte/lymphocyte ratio(MLR),and neutrophil/lymphocyte ratio(NLR)were significantly positively correlated with influenza A virus infection(P＜0.01).The RCS analysis exhibited the same trend.The age subgroup analysis showed that when the age was greater than 6 years,LYM was significantly negatively correlated with influenza A virus infection(P＜0.01).When the age was greater than 12 years,MLR was significantly positively correlated with influenza A virus infec-tion(P＜0.01).Conclusion The WBC,LY％,LYM,NE％,MLR,and NLR in CBC parameters are important indicators associated with the occurrence of Influenza A virus infection,especially LYM in patients aged over 6 years and MLR in patients aged over 12 years,which may serve as biomarkers for the diagnosis and differential diagnosis of influenza A virus infection.
